Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
|
|
YouTube Encyclopedic
-
1/3Views:2 850574432
-
Terminal Complement Deficiencies - CRASH! Medical Review Series
-
The Classical Complement Pathway Part 4
-
13. Effector Mechanisms of Humoral Immunity (Raje)
Transcription
Structure
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
- ^ PDB: 3OJY; Lovelace LL, Cooper CL, Sodetz JM, Lebioda L (May 2011). "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement". The Journal of Biological Chemistry. 286 (20): 17585–92. doi:10.1074/jbc.M111.219766. PMC 3093833. PMID 21454577.
External links
- Complement+C8 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it. |
This page was last edited on 14 March 2022, at 04:29