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Bradley Peterson

From Wikipedia, the free encyclopedia

Bradley S. Peterson
Occupation(s)Adult and child psychiatrist, developmental neuroscientist, academic and author
Academic background
EducationB.S., Philosophy
M.D.
Alma materTulane University
St. Catherine’s College, Oxford University
University of Wisconsin–Madison Medical School
Harvard University
Yale University
Academic work
InstitutionsYale University
Columbia University
University of Southern California

Bradley S. Peterson is an American psychiatrist, developmental neuroscientist, academic and author. He is the Inaugural Director of the Institute for the Developing Mind at Children's Hospital Los Angeles (CHLA), and holds the positions of Vice Chair for Research and Chief of the Division of Child & Adolescent Psychiatry in the Department of Psychiatry at the Keck School of Medicine at the University of Southern California.[1]

Peterson is most known for his neuroscience research on neuropsychiatric disorders including autism, depression, bipolar disorder, ADHD, Tourette syndrome, obsessive-compulsive disorder, schizophrenia, and eating disorders, as well as premature birth, the effects of environmental toxins on brain development, and brain mechanisms that mediate the effects of treatments on clinical outcomes. He has also studied normal brain development, and brain processes that support normal cognitive and emotional processes.[2]

Peterson was named Outstanding Mentor by the American Academy of Child & Adolescent Psychiatry in 2006 and 2014,[3] and he is the recipient of the 2007 Columbia University John J. Weber Prize for Outstanding Research,[4] the 2012 American Psychiatric Association Blanche Ittleson Award,[5] the 2024 Leadership in Child, Adolescent and Young Adult Psychiatry from the American College of Psychiatrists, the 2012 Excellence in Teaching Award from the New York Presbyterian Hospital of Columbia and Cornell Universities, and the 2017 and 2020 USC Keck School of Medicine Dean's Teaching Award.[1]

Peterson is a Fellow of the American College of Neuropsychopharmacology and the American College of Psychiatrists.[6] He is the Editor for the Neuroscience Section of the Journal of Child Psychology & Psychiatry.[7]

Education and early career

Peterson graduated with a bachelor's degree in Philosophy from Tulane University in 1983 and an M.D. from the University of Wisconsin–Madison Medical School in 1987 and also studied philosophy at St. Catherine's College of Oxford University.[1]

Career

Peterson began his academic career at the Yale School of Medicine as an Assistant Professor in Child Psychiatry in 1994, the Elizabeth Meers and House Jameson Assistant/Associate Professor in 1996 and associate professor in 2000. In 2001, he became an Associate Professor in Child Psychiatry at the Columbia College of Physicians & Surgeons from 2001 to 2014 and a professor in psychiatry from 2005 to 2014.[8] Subsequently, he joined the University of Southern California as a professor in the Department of Psychiatry in 2014.[1]

Since 2017, he has been the Director of Child & Adolescent Psychiatry since 2014 and the Vice Chair for Research in the Department of Psychiatry of the Keck School of Medicine at the University of Southern California.[1] He has been the Director of the Institute for the Developing Mind at Children's Hospital Los Angeles since 2014, where he has also served as Interim Chief Scientific Officer from 2016 to 2018, Chief of Psychiatry since 2019, and co-director of the Behavioral Health Institute since 2022.[9]

Research

Peterson has studied normal brain development across the life span, normal and pathological impulse control, prenatal exposures, emotional processing and mood disorders, Autism Spectrum Disorders, and the development of new MRI methods.[2]

Normal brain development

Peterson has investigated normal brain development, normal aging, normal cognitive and emotional processes, and self-regulatory control. He and his colleagues demonstrated that gray matter density declines nonlinearly with age in frontal and parietal cortices from early childhood to approximately age 40, and declining in the left posterior temporal region beginning approximately at age 60, indicating that cortical maturation and aging trajectories vary across the brain.[10] In addition, he showed that brain tissue microstructure and metabolites mature in frontal and cingulate cortices and contribute to improved self-regulation during the transition from childhood to adolescence.[11] He further demonstrated age-related increases in prefrontal cortex and basal ganglia activation during a Stroop task was associated with improved self-regulatory control, indicating maturation of frontostriatal systems from childhood through adulthood in healthy individuals.[12]

Peterson has studied normal cognitive and emotional processing in the brain as well. He and his colleagues, including James Russell, developed an emotion processing task based on the Circumplex Model of Affect[13] that explored with functional MRI the neural systems that independently subserve the valence and arousal components of a full range of normal emotions evoked by emotional words,[14] faces,[15][16] and induced moods.[17] In collaboration with Mark Packard, he developed a virtual reality platform for use during functional MRI scanning to study procedural and declarative learning processes in both health[18][19] and illness.[20]

Disorders of impulse control

Peterson has researched disorders of impulse control, including Tourette's Syndrome (TS), Obsessive-Compulsive Disorder (OCD), and Attention-Deficit/Hyperactivity Disorder (ADHD). His imaging studies of TS subjects and controls across the lifespan have demonstrated larger prefrontal cortices in TS children, with an inverse association of these regional volumes with tic symptom severity.[21] Prefrontal volumes in TS adults, however, were smaller than control values, likely due to the ascertainment bias of studying still-symptomatic adults, given that tic symptoms usually substantially improve by adulthood.[22] These findings, along with earlier observations of significant prefrontal activation during tic suppression, suggested that compensatory responses involving activity-dependent plasticity and prefrontal hypertrophy play a role in controlling tic symptoms.[23][24] He also established that caudate volumes in TS children predict the severity of both tics and OCD symptoms in early adulthood, even after adjusting for potential confounds.[25] These collective results suggested that prefrontal hypertrophy acts as a compensatory response to the presence of tics, attenuating symptoms in temporal proximity to the time of volume measurement. Conversely, the magnitude of the abnormality in the caudate nucleus is more critical in predicting the long-term outcome of symptom severity in TS.[26]

In addition, Peterson showed the presence of prominent cortical thinning in ventral portions of the sensory and motor homunculi that control the facial and vocal muscles that are commonly involved in tic symptoms.[27] More severe thinning was associated with more severe tic symptoms, suggesting that these sensorimotor regions are important in producing tics. He also explored neural mechanisms that generate the tics, comparing brain activation during spontaneous tics in persons with TS and mimicked tics in healthy controls. Finding showed that the sensory urges that generate tics derive from greater neural activity in somatosensory cortices, putamen, and amygdala/hippocampus complex, whereas progressively weaker activity in cortical-subcortical regulatory circuits (especially the caudate and anterior cingulate cortex) accompany proportionately more severe symptoms, highlighting that faulty activity in these circuits fail to control tic behaviors and the sensory urges that generate them.[28] Faulty activity within the subcortical portions of these circuits was further implicated in his showing that habit learning processes based within the striatum (caudate and putamen) are impaired in persons with TS in direct proportion to the severity of tic symptoms.[29]

Peterson's functional and anatomical studies have helped to define the neural basis of ADHD. A morphological study of the cortical surface, published in The Lancet, revealed smaller volumes of inferior prefrontal and anterior temporal regions in children with ADHD, supporting the hypothesis of involvement of these regions in the pathophysiology of the disorder.[30] Several of his functional imaging studies documented the significance of these regions in attention and behavior regulation. He demonstrated abnormal default-mode activity in ventral anterior cingulate and posterior cingulate cortices in ADHD youth, with these abnormalities normalizing in response to stimulant medications.[31] Additionally, he showcased that stimulant medications may reverse morphological abnormalities in the basal ganglia and thalamus of youth with ADHD.[32][33] He also presented evidence for neuroplastic hypertrophy in the hippocampus and amygdala of ADHD youth, potentially serving as a compensatory response to dysfunctional frontostriatal circuits elsewhere in the brain and contributing to the attenuation of ADHD symptoms.[34]

Neonatal risks

Peterson's work on neonatal risks focused on conditions that confer risk for disturbances in development of the neonatal CNS, including premature birth, prenatal exposure to drugs of abuse, and prenatal exposure to various common environmental toxins.[2]

Peterson published the first quantitative study of the long-term effects of preterm birth on brain development, revealing large reductions in the volumes of specific cortical regions in the preterm children, most prominently in sensorimotor regions but also in premotor, midtemporal, parieto-occipital, and subgenual cortices, correlating with IQ at age 8 and gestational age at birth, indicating that younger birth age is associated with greater abnormalities in brain structure, and larger abnormalities in brain structure are associated with lower IQ.[35] Using fMRI in the same group, he demonstrated that while term-born children activated typical language areas during meaningful speech perception, prematurely born children activated these regions during meaningful speech similarly to how term-born children responded to nonsensical, phonemic sounds.[36] He concluded that the unusual activation during meaningful speech in preterm children was linked to lower verbal IQ and reduced comprehension of meaningful stories.[37] Subsequently, he examined brain volumes in preterm and term infants near their term due dates, observing a consistent pattern of anatomical abnormalities similar to those identified in 8-year-old prematurely born infants, suggesting that specific brain region morphological abnormalities are present soon after preterm birth.[38]

In addition, Peterson conducted imaging on a cohort of over 180 newborns, with 45 exposed in utero to crack cocaine, 45 to narcotics, 45 to cannabis, and 45 unexposed to any drugs of abuse, finding notable abnormalities in brain structure, connectivity, and function in drug-exposed infants at birth.[39] He collaborated with researchers at Columbia's School of Public Health, scanning 450 children in a longitudinal study on the impact of prenatal exposure to environmental toxins, including household insecticides, and found that prenatal exposure to the organophosphate insecticide chlorpyrifos increased white matter volumes in specific brain regions in proportion to cumulative exposure and associated IQ impairment, influencing an FDA review of chlorpyrifos use in the U.S. as an agricultural pesticide.[40] Furthermore, he showcased that prenatal exposure to PM2.5 and PAH disrupts brain development in youth, affecting anatomy, microstructure, and function, with implications for cognitive, emotional, and behavioral outcomes.[41]

Affective disorders

Peterson has studied the brain bases of affective disorders, including Bipolar Disorder and Major Depression. Using a self-regulatory task, he found that adults with BD exhibited deficient left inferior prefrontal cortex activation, indicating a potential trait abnormality. The BD group also showed reduced amygdala (16%) and hippocampus (5%) volumes, likely emerging early in the illness course.[42] These and other related findings suggested the presence of faulty circuits that regulate emotions, with mesial temporal lobe structures losing normal top-down control from frontal cortices, potentially generating the mood changes of BD.[43]

Peterson, along with Myrna Weissman and colleagues, identified a brain-based endophenotype for Major Depressive Disorder (MDD), characterized by cortical thinning across the lateral surface of the right hemisphere and associated white matter abnormalities.[44][45] This endophenotype, linked to familial risk for MDD, correlated with inattention and poor visual memory. He established neural patterns associated with depression risk (cortical attention circuits), resilience (dorsal anterior cingulate cortex), and enduring effects following illness (default mode circuits) as well, highlighting potential endophenotypes for novel interventions.[46]

Additionally, Peterson demonstrated that treatment with duloxetine attenuates and normalizes excessive activity and network connectivity in dysthymic individuals.[47] His research also illuminated that in patients with depressive disorders, duloxetine treatment induces changes in cortical gray matter morphology that likely represent neuroanatomical plasticity, and it normalizes N-acetyl-aspartate (NAA) concentrations by modulating depressive symptom severity, revealing the relationship between neurochemistry and depressive symptoms.[48][49]

Autism Spectrum Disorders

Peterson used multiple MRI modalities to explore the brain basis for the heterogeneity of symptoms in Autism Spectrum Disorder (ASD). He observed that brain lactate, indicating the presence of mitochondrial dysfunction, was significantly greater in individuals with ASD, suggesting a possible neurobiological subtype of ASD.[50] He also found that metabolite concentrations were altered in regions of the brain subserving socialization in persons with ASD, and in proportion to the severity of ASD symptom scores.[51] In another study, participants with ASD showed widespread alterations in regional brain blood flow, correlating with socialization deficits and suggesting potential metabolic disturbances that impact neural efficiency and trigger compensatory glial responses.[52] Alongside colleagues, he showed that ASD participants exhibited altered white matter microstructure that adversely impact blood flow, symptoms, and cognitive abilities.[53] He further used functional MRI to demonstrate that persons with ASD processed and likely experienced emotional stimuli very differently from the way typically developing persons did, and moreover that these differences were specific to the arousal components of facial emotions but not valence components.[54]

Development of new imaging technologies

Peterson led a research program with collaborators that developed new methods for acquisition and processing of MRI data, including deformation-based analyses for anatomical data processing, noise reduction in diffusion tensor images,[55] statistical techniques for intergroup comparison of diffusion tensor images, enhanced signal-to-noise ratios in spectroscopic images,[56] and improved head coils for human and animal imaging.[57] His team developed software supporting virtual reality platforms for use in fMRI scanning.[58] Furthermore, he and Ravi Bansal developed software capable of diagnosing psychiatric disorders based solely on an individual's anatomical brain image.[59][60]

Awards and honors

  • 2006, 2014 – Outstanding Mentor, the American Academy of Child & Adolescent Psychiatry[3]
  • 2007 – John J. Weber Prize, Columbia University[4]
  • 2012 – Blanche Ittleson Award, American Psychiatric Association[5]
  • 2012 – Excellence in Teaching, New York Presbyterian Hospital of Columbia and Cornell Universities
  • 2017 – Dean's Teaching Award, Keck School of Medicine[1]
  • 2024 – Leadership in Child, Adolescent and Young Adult Psychiatry, American College of Psychiatrists

Selected articles

  • Peterson, B. S., Skudlarski, P., Gatenby, J. C., Zhang, H., Anderson, A. W., & Gore, J. C. (1999). An fMRI study of Stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Biological psychiatry, 45(10), 1237–1258.
  • Peterson, B. S., Vohr, B., Staib, L. H., Cannistraci, C. J., Dolberg, A., Schneider, K. C., ... & Ment, L. R. (2000). Regional brain volume abnormalities and long-term cognitive outcome in preterm infants. JAMA, 284, 1939–1947.
  • Sowell, E. R., Thompson, P. M., Welcome, S. E., Henkenius, A. L., Toga, A. W., & Peterson, B. S. (2003). Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder. The Lancet, 362(9397), 1699–1707.
  • Posner, J., Russell, J. A., & Peterson, B. S. (2005). The circumplex model of affect: An integrative approach to affective neuroscience, cognitive development, and psychopathology. Development and psychopathology, 17(3), 715–734.
  • Sowell, E. R., Kan, E., Yoshii, J., Thompson, P. M., Bansal, R., Xu, D., ... & Peterson, B. S. (2008). Thinning of sensorimotor cortices in children with Tourette syndrome. Nature neuroscience, 11(6), 637–639.
  • Peterson, B. S., Warner, V., Bansal, R., Zhu, H., Hao, X., Liu, J., ... & Weissman, M. M. (2009). Cortical thinning in persons at increased familial risk for major depression. Proceedings of the National Academy of Sciences, 106(15), 6273–6278.
  • Tau, G. Z., & Peterson, B. S. (2010). Normal development of brain circuits. Neuropsychopharmacology, 35(1), 147–168.
  • Peterson, B. S., Rosen, T., Dingman, S., Toth, Z. R., Sawardekar, S., Hao, X., ... & Bansal, R. (2020). Associations of maternal prenatal drug abuse with measures of newborn brain structure, tissue organization, and metabolite concentrations. JAMA pediatrics, 174(9), 831–842.
  • Siegel, P., Wang, Z., Murray, L., Campos, J., Sims, V., Leighton, E., & Peterson, B. S. (2020). Brain-based mediation of non-conscious reduction of phobic avoidance in young women during functional MRI: a randomised controlled experiment. The Lancet Psychiatry, 7(11), 971–981.
  • Peterson, B. S., Bansal, R., Sawardekar, S., Nati, C., Elgabalawy, E. R., Hoepner, L. A., ... & Rauh, V. (2022). Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood. Journal of Child Psychology and Psychiatry, 63(11), 1316–1331.

References

  1. ^ a b c d e f "Bradley Peterson, MD". Keck School of Medicine of USC.
  2. ^ a b c "Bradley S. Peterson, M.D." scholar.google.com.
  3. ^ a b "AACAP Pilot Research Award Recipients". www.aacap.org.
  4. ^ a b "Awards". Columbia University Department of Psychiatry. August 6, 2023.
  5. ^ a b "APA Council Reports". American Journal of Psychiatry. 170 (2): 228–236. February 12, 2013. doi:10.1176/appi.ajp.2012.1700201 – via ajp.psychiatryonline.org (Atypon).
  6. ^ "Member Search".
  7. ^ "Editorial Board - Journal of Child Psychology and Psychiatry - Wiley Online Library".
  8. ^ "Bradley S. Peterson".
  9. ^ "Bradley Peterson, MD". Children's Hospital Los Angeles.
  10. ^ Sowell, Elizabeth R.; Peterson, Bradley S.; Thompson, Paul M.; Welcome, Suzanne E.; Henkenius, Amy L.; Toga, Arthur W. (March 12, 2003). "Mapping cortical change across the human life span". Nature Neuroscience. 6 (3): 309–315. doi:10.1038/nn1008. PMID 12548289. S2CID 23799692 – via www.nature.com.
  11. ^ Nelson, Mary Baron; O'Neil, Sharon H.; Wisnowski, Jessica L.; Hart, Danielle; Sawardekar, Siddhant; Rauh, Virginia; Perera, Frederica; Andrews, Howard F.; Hoepner, Lori A.; Garcia, Wanda; Algermissen, Molly; Bansal, Ravi; Peterson, Bradley S. (October 16, 2019). "Maturation of Brain Microstructure and Metabolism Associates with Increased Capacity for Self-Regulation during the Transition from Childhood to Adolescence". Journal of Neuroscience. 39 (42): 8362–8375. doi:10.1523/JNEUROSCI.2422-18.2019. PMC 6794926. PMID 31444243 – via www.jneurosci.org.
  12. ^ Marsh, Rachel; Zhu, Hongtu; Schultz, Robert T.; Quackenbush, Georgette; Royal, Jason; Skudlarski, Pawel; Peterson, Bradley S. (November 12, 2006). "A developmental fMRI study of self-regulatory control". Human Brain Mapping. 27 (11): 848–863. doi:10.1002/hbm.20225. PMC 2292452. PMID 16421886.
  13. ^ Posner, Jonathan; Russell, James A.; Peterson, Bradley S. (September 12, 2005). "The circumplex model of affect: An integrative approach to affective neuroscience, cognitive development, and psychopathology". Development and Psychopathology. 17 (3): 715–734. doi:10.1017/S0954579405050340. PMC 2367156. PMID 16262989.
  14. ^ Posner, Jonathan; Russell, James A.; Gerber, Andrew; Gorman, Daniel; Colibazzi, Tiziano; Yu, Shan; Wang, Zhishun; Kangarlu, Alayar; Zhu, Hongtu; Peterson, Bradley S. (March 12, 2009). "The neurophysiological bases of emotion: An fMRI study of the affective circumplex using emotion-denoting words". Human Brain Mapping. 30 (3): 883–895. doi:10.1002/hbm.20553. PMC 2644729. PMID 18344175.
  15. ^ Gerber, Andrew J.; Posner, Jonathan; Gorman, Daniel; Colibazzi, Tiziano; Yu, Shan; Wang, Zhishun; Kangarlu, Alayar; Zhu, Hongtu; Russell, James; Peterson, Bradley S. (July 1, 2008). "An affective circumplex model of neural systems subserving valence, arousal, and cognitive overlay during the appraisal of emotional faces". Neuropsychologia. 46 (8): 2129–2139. doi:10.1016/j.neuropsychologia.2008.02.032. PMC 2486369. PMID 18440572.
  16. ^ Tseng, Angela; Bansal, Ravi; Liu, Jun; Gerber, Andrew J.; Goh, Suzanne; Posner, Jonathan; Colibazzi, Tiziano; Algermissen, Molly; Chiang, I-Chin; Russell, James A.; Peterson, Bradley S. (June 1, 2014). "Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders". Journal of Autism and Developmental Disorders. 44 (6): 1332–1346. doi:10.1007/s10803-013-1993-6. PMC 4301408. PMID 24234677 – via Springer Link.
  17. ^ Colibazzi, Tiziano; Posner, Jonathan; Wang, Zhishun; Gorman, Daniel; Gerber, Andrew; Yu, Shan; Zhu, Hongtu; Kangarlu, Alayar; Duan, Yunsuo; Russell, James A.; Peterson, Bradley S. (February 12, 2010). "Neural systems subserving valence and arousal during the experience of induced emotions". Emotion. 10 (3): 377–389. doi:10.1037/a0018484. PMID 20515226. S2CID 4849117 – via CrossRef.
  18. ^ Marsh, Rachel; Hao, Xuejun; Xu, Dongrong; Wang, Zhishun; Duan, Yunsuo; Liu, Jun; Kangarlu, Alayar; Martinez, Diana; Garcia, Felix; Tau, Gregory Z.; Yu, Shan; Packard, Mark G.; Peterson, Bradley S. (August 1, 2010). "A virtual reality-based FMRI study of reward-based spatial learning". Neuropsychologia. 48 (10): 2912–2921. doi:10.1016/j.neuropsychologia.2010.05.033. PMC 2914178. PMID 20570684.
  19. ^ Horga, Guillermo; Maia, Tiago V.; Marsh, Rachel; Hao, Xuejun; Xu, Dongrong; Duan, Yunsuo; Tau, Gregory Z.; Graniello, Barbara; Wang, Zhishun; Kangarlu, Alayar; Martinez, Diana; Packard, Mark G.; Peterson, Bradley S. (February 12, 2015). "Changes in corticostriatal connectivity during reinforcement learning in humans". Human Brain Mapping. 36 (2): 793–803. doi:10.1002/hbm.22665. PMC 4332407. PMID 25393839.
  20. ^ Tau, Gregory Z.; Marsh, Rachel; Wang, Zhishun; Torres-Sanchez, Tania; Graniello, Barbara; Hao, Xuejun; Xu, Dongrong; Packard, Mark G.; Duan, Yunsuo; Kangarlu, Alayar; Martinez, Diana; Peterson, Bradley S. (February 12, 2014). "Neural Correlates of Reward-Based Spatial Learning in Persons with Cocaine Dependence". Neuropsychopharmacology. 39 (3): 545–555. doi:10.1038/npp.2013.189. PMC 3895231. PMID 23917430.
  21. ^ Peterson, Bradley S.; Staib, Lawrence; Scahill, Lawrence; Zhang, Heping; Anderson, Carol; Leckman, James F.; Cohen, Donald J.; Gore, John C.; Albert, John; Webster, Rebecca (2001). "Regional brain and ventricular volumes in Tourette syndrome". Archives of General Psychiatry. 58 (5): 427–440. doi:10.1001/archpsyc.58.5.427. PMID 11343521. S2CID 10260320.
  22. ^ Margolis, Amy; Donkervoort, Mireille; Kinsbourne, Marcel; Peterson, Bradley S. (February 12, 2006). "Interhemispheric connectivity and executive functioning in adults with Tourette syndrome". Neuropsychology. 20 (1): 66–76. doi:10.1037/0894-4105.20.1.66. PMC 2364723. PMID 16460223.
  23. ^ Plessen, Kerstin J.; Grüner, Renate; Lundervold, Arvid; Hirsch, Jochen G.; Xu, Dongrong; Bansal, Ravi; Hammar, Åsa; Lundervold, Astri J.; Wentzel-Larsen, Tore; Lie, Stein Atle; Gass, Achim; Peterson, Bradley S.; Hugdahl, Kenneth (November 12, 2006). "Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome". Journal of Child Psychology and Psychiatry. 47 (10): 1013–1022. doi:10.1111/j.1469-7610.2006.01639.x. PMC 2367126. PMID 17073980.
  24. ^ Plessen, Kerstin J.; Bansal, Ravi; Peterson, Bradley S. (December 1, 2009). "Imaging evidence for anatomical disturbances and neuroplastic compensation in persons with Tourette syndrome". Journal of Psychosomatic Research. 67 (6): 559–573. doi:10.1016/j.jpsychores.2009.07.005. PMC 4283588. PMID 19913660.
  25. ^ Bloch, Michael H.; Leckman, James F.; Zhu, Hongtu; Peterson, Bradley S. (October 25, 2005). "Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome". Neurology. 65 (8): 1253–1258. doi:10.1212/01.wnl.0000180957.98702.69. PMC 2367161. PMID 16247053.
  26. ^ Peterson, Bradley S.; Choi, Huimahn A.; Hao, Xuejun; Amat, Jose A.; Zhu, Hongtu; Whiteman, Ronald; Liu, Jun; Xu, Dongrong; Bansal, Ravi (2007). "Morphologic Features of the Amygdala and Hippocampus in Children and Adults With Tourette Syndrome". Archives of General Psychiatry. 64 (11): 1281–1291. doi:10.1001/archpsyc.64.11.1281. PMC 2291296. PMID 17984397.
  27. ^ Sowell, Elizabeth R.; Kan, Eric; Yoshii, June; Thompson, Paul M.; Bansal, Ravi; Xu, Dongrong; Toga, Arthur W.; Peterson, Bradley S. (June 12, 2008). "Thinning of sensorimotor cortices in children with Tourette syndrome". Nature Neuroscience. 11 (6): 637–639. doi:10.1038/nn.2121. PMC 2605107. PMID 18488025.
  28. ^ Wang, Zhishun; Maia, Tiago V.; Marsh, Rachel; Colibazzi, Tiziano; Gerber, Andrew; Peterson, Bradley S. (December 12, 2011). "The Neural Circuits That Generate Tics in Tourette's Syndrome". American Journal of Psychiatry. 168 (12): 1326–1337. doi:10.1176/appi.ajp.2011.09111692. PMC 4246702. PMID 21955933.
  29. ^ Marsh, R.; Alexander, G. M.; Packard, M. G.; Zhu, H.; Wingard, J. C.; Quackenbush, G.; Peterson, B. S. (2004). "Habit learning in Tourette syndrome: a translational neuroscience approach to a developmental psychopathology". Archives of General Psychiatry. 61 (12): 1259–1268. doi:10.1001/archpsyc.61.12.1259. PMID 15583117.
  30. ^ Sowell, Elizabeth R; Thompson, Paul M; Welcome, Suzanne E; Henkenius, Amy L; Toga, Arthur W; Peterson, Bradley S (November 12, 2003). "Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder". The Lancet. 362 (9397): 1699–1707. doi:10.1016/s0140-6736(03)14842-8. PMID 14643117. S2CID 35522357.
  31. ^ Peterson, Bradley S.; Potenza, Marc N.; Wang, Zhishun; Zhu, Hongtu; Martin, Andrés; Marsh, Rachel; Plessen, Kerstin J.; Yu, Shan (November 12, 2009). "An fMRI Study of the Effects of Psychostimulants on Default-Mode Processing During Stroop Task Performance in Youths With ADHD". American Journal of Psychiatry. 166 (11): 1286–1294. doi:10.1176/appi.ajp.2009.08050724. PMC 3289412. PMID 19755575.
  32. ^ Ivanov, Iliyan; Bansal, Ravi; Hao, Xuejun; Zhu, Hongtu; Kellendonk, Cristoph; Miller, Loren; Sanchez-Pena, Juan; Miller, Ann M.; Chakravarty, M. Mallar; Klahr, Kristin; Durkin, Kathleen; Greenhill, Laurence L.; Peterson, Bradley S. (April 12, 2010). "Morphological Abnormalities of the Thalamus in Youths With Attention Deficit Hyperactivity Disorder". American Journal of Psychiatry. 167 (4): 397–408. doi:10.1176/appi.ajp.2009.09030398. PMC 4282161. PMID 20123910.
  33. ^ Sobel, Loren J.; Bansal, Ravi; Maia, Tiago V.; Sanchez, Juan; Mazzone, Luigi; Durkin, Kathleen; Liu, Jun; Hao, Xuejun; Ivanov, Iliyan; Miller, Ann; Greenhill, Laurence L.; Peterson, Bradley S. (August 12, 2010). "Basal Ganglia Surface Morphology and the Effects of Stimulant Medications in Youth With Attention Deficit Hyperactivity Disorder". American Journal of Psychiatry. 167 (8): 977–986. doi:10.1176/appi.ajp.2010.09091259. PMC 4254769. PMID 20595414.
  34. ^ Plessen, Kerstin J.; Bansal, Ravi; Zhu, Hongtu; Whiteman, Ronald; Amat, Jose; Quackenbush, Georgette A.; Martin, Laura; Durkin, Kathleen; Blair, Clancy; Royal, Jason; Hugdahl, Kenneth; Peterson, Bradley S. (2006). "Hippocampus and Amygdala Morphology in Attention-Deficit/Hyperactivity Disorder". Archives of General Psychiatry. 63 (7): 795–807. doi:10.1001/archpsyc.63.7.795. PMC 2367150. PMID 16818869.
  35. ^ Peterson, Bradley S.; Vohr, Betty; Staib, Lawrence H.; Cannistraci, Christopher J.; Dolberg, Aaron; Schneider, Karen C.; Katz, Karol H.; Westerveld, Michael; Sparrow, Sara; Anderson, Adam W.; Duncan, Charles C.; Makuch, Robert W.; Gore, John C.; Ment, Laura R. (2022). "Regional Brain Volume Abnormalities and Long-term Cognitive Outcome in Preterm Infants". The Science of Mental Health. pp. 215–223. doi:10.4324/9780203822937-21. ISBN 978-0-203-82293-7.
  36. ^ Ment, Laura R.; Vohr, Betty R.; Schneider, Karen A.; Katz, Karol; Cannistraci, Christopher; Fulbright, Robert; Peterson, Bradley (April 12, 1999). "Functional Magnetic Resonance Imaging (fMRI) Assessment of Language Systems in Very Low Birth Weight (VLBW) Preterm Infants". Pediatric Research. 45 (7): 344. doi:10.1203/00006450-199904020-02046 – via www.nature.com.
  37. ^ Peterson, Bradley S.; Vohr, Betty; Kane, Michael J.; Whalen, Douglas H.; Schneider, Karen C.; Katz, Karol H.; Zhang, Heping; Duncan, Charles C.; Makuch, Robert; Gore, John C.; Ment, Laura R. (2002). "A Functional Magnetic Resonance Imaging Study of Language Processing and Its Cognitive Correlates in Prematurely Born Children". Pediatrics. 110 (6): 1153–1162. doi:10.1542/peds.110.6.1153. PMID 12456913.
  38. ^ Peterson, Bradley S.; Anderson, Adam W.; Ehrenkranz, Richard; Staib, Lawrence H.; Tageldin, Magdi; Colson, Eve; Gore, John C.; Duncan, Charles C.; Makuch, Robert; Ment, Laura R. (2003). "Regional Brain Volumes and Their Later Neurodevelopmental Correlates in Term and Preterm Infants". Pediatrics. 111 (5): 939–948. doi:10.1542/peds.111.5.939. PMID 12728069.
  39. ^ Peterson, Bradley S.; Rosen, Tove; Dingman, Sherry; Toth, Zachary R.; Sawardekar, Siddhant; Hao, Xuejun; Liu, Feng; Xu, Dongrong; Dong, Zhengchao; Peterson, Jarod B.; Ryoo, Ji Hoon; Serino, Dana; Branch, Craig A.; Bansal, Ravi (2020). "Associations of Maternal Prenatal Drug Abuse With Measures of Newborn Brain Structure, Tissue Organization, and Metabolite Concentrations". JAMA Pediatrics. 174 (9): 831–842. doi:10.1001/jamapediatrics.2020.1622. PMC 7296459. PMID 32539126.
  40. ^ Rauh, Virginia A.; Perera, Frederica P.; Horton, Megan K.; Whyatt, Robin M.; Bansal, Ravi; Hao, Xuejun; Liu, Jun; Barr, Dana Boyd; Slotkin, Theodore A.; Peterson, Bradley S. (May 15, 2012). "Brain anomalies in children exposed prenatally to a common organophosphate pesticide". Proceedings of the National Academy of Sciences. 109 (20): 7871–7876. Bibcode:2012PNAS..109.7871R. doi:10.1073/pnas.1203396109. PMC 3356641. PMID 22547821.
  41. ^ Peterson, Bradley S.; Bansal, Ravi; Sawardekar, Siddhant; Nati, Carlo; Elgabalawy, Eman R.; Hoepner, Lori A.; Garcia, Wanda; Hao, Xuejun; Margolis, Amy; Perera, Frederica; Rauh, Virginia (November 12, 2022). "Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood". Journal of Child Psychology and Psychiatry. 63 (11): 1316–1331. doi:10.1111/jcpp.13578. PMID 35165899. S2CID 246825991 – via CrossRef.
  42. ^ Blumberg, Hilary P.; Kaufman, Joan; Martin, Andrés; Whiteman, Ronald; Zhang, Jane Hongyuan; Gore, John C.; Charney, Dennis S.; Krystal, John H.; Peterson, Bradley S. (2003). "Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder". Archives of General Psychiatry. 60 (12): 1201–1208. doi:10.1001/archpsyc.60.12.1201. PMID 14662552.
  43. ^ Blumberg, H. P.; Leung, H. C.; Skudlarski, P.; Lacadie, C. M.; Fredericks, C. A.; Harris, B. C.; Charney, D. S.; Gore, J. C.; Krystal, J. H.; Peterson, B. S. (2003). "A Functional Magnetic Resonance Imaging Study of Bipolar Disorder State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices". Archives of General Psychiatry. 60 (6): 601–609. doi:10.1001/archpsyc.60.6.601. PMID 12796223.
  44. ^ Peterson, Bradley S.; Weissman, Myrna M. (February 18, 2011). "A Brain-Based Endophenotype for Major Depressive Disorder". Annual Review of Medicine. 62 (1): 461–474. doi:10.1146/annurev-med-010510-095632. PMC 3269401. PMID 21226617.
  45. ^ Peterson, Bradley S.; Warner, Virginia; Bansal, Ravi; Zhu, Hongtu; Hao, Xuejun; Liu, Jun; Durkin, Kathleen; Adams, Phillip B.; Wickramaratne, Priya; Weissman, Myrna M. (April 14, 2009). "Cortical thinning in persons at increased familial risk for major depression". Proceedings of the National Academy of Sciences. 106 (15): 6273–6278. Bibcode:2009PNAS..106.6273P. doi:10.1073/pnas.0805311106. PMC 2669378. PMID 19329490.
  46. ^ Peterson, Bradley S.; Wang, Zhishun; Horga, Guillermo; Warner, Virginia; Rutherford, Bret; Klahr, Kristin W.; Graniello, Barbara; Wickramaratne, Priya; Garcia, Felix; Yu, Shan; Hao, Xuejun; Adams, Phillip B.; Qian, Ming; Liu, Jun; Gerber, Andrew; Weissman, Myrna M. (February 1, 2014). "Discriminating Risk and Resilience Endophenotypes From Lifetime Illness Effects in Familial Major Depressive Disorder". JAMA Psychiatry. 71 (2): 136–148. doi:10.1001/jamapsychiatry.2013.4048. PMC 3965257. PMID 24369340.
  47. ^ Posner, Jonathan; Hellerstein, David J.; Gat, Inbal; Mechling, Anna; Klahr, Kristin; Wang, Zhishun; McGrath, Patrick J.; Stewart, Jonathan W.; Peterson, Bradley S. (April 1, 2013). "Antidepressants Normalize the Default Mode Network in Patients With Dysthymia". JAMA Psychiatry. 70 (4): 373–382. doi:10.1001/jamapsychiatry.2013.455. PMC 3935731. PMID 23389382.
  48. ^ Bansal, Ravi; Hellerstein, David J.; Sawardekar, Siddhant; O’Neill, Joseph; Peterson, Bradley S. (July 19, 2019). "Effects of the antidepressant medication duloxetine on brain metabolites in persistent depressive disorder: A randomized, controlled trial". PLOS ONE. 14 (7): e0219679. Bibcode:2019PLoSO..1419679B. doi:10.1371/journal.pone.0219679. PMC 6641507. PMID 31323045.
  49. ^ Bansal, R.; Hellerstein, D. J.; Peterson, B. S. (February 12, 2018). "Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness". Molecular Psychiatry. 23 (2): 375–383. doi:10.1038/mp.2017.34. PMC 5589468. PMID 28265119.
  50. ^ Goh, Suzanne; Dong, Zhengchao; Zhang, Yudong; DiMauro, Salvatore; Peterson, Bradley S. (June 1, 2014). "Mitochondrial Dysfunction as a Neurobiological Subtype of Autism Spectrum Disorder: Evidence From Brain Imaging". JAMA Psychiatry. 71 (6): 665–671. doi:10.1001/jamapsychiatry.2014.179. PMC 4239991. PMID 24718932.
  51. ^ O’Neill, Joseph; Bansal, Ravi; Goh, Suzanne; Rodie, Martina; Sawardekar, Siddhant; Peterson, Bradley S. (January 12, 2020). "Parsing the Heterogeneity of Brain Metabolic Disturbances in Autism Spectrum Disorder". Biological Psychiatry. 87 (2): 174–184. doi:10.1016/j.biopsych.2019.06.010. PMC 6925333. PMID 31427037.
  52. ^ Peterson, Bradley S.; Zargarian, Ariana; Peterson, Jarod B.; Goh, Suzanne; Sawardekar, Siddhant; Williams, Steven C.R.; Lythgoe, David J.; Zelaya, Fernando O.; Bansal, Ravi (April 12, 2019). "Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder". Biological Psychiatry. 85 (7): 584–595. doi:10.1016/j.biopsych.2018.11.026. PMC 6420395. PMID 30711191.
  53. ^ Peterson, Bradley S.; Liu, Jiaqi; Dantec, Louis; Newman, Courtney; Sawardekar, Siddhant; Goh, Suzanne; Bansal, Ravi (August 12, 2022). "Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder". Journal of Child Psychology and Psychiatry. 63 (8): 855–870. doi:10.1111/jcpp.13531. PMC 9091058. PMID 34762311.
  54. ^ Tseng, Angela; Wang, Zhishun; Huo, Yuankai; Goh, Suzanne; Russell, James A.; Peterson, Bradley S. (February 12, 2016). "Differences in neural activity when processing emotional arousal and valence in autism spectrum disorders". Human Brain Mapping. 37 (2): 443–461. doi:10.1002/hbm.23041. PMC 4734135. PMID 26526072.
  55. ^ Bansal, Ravi; Staib, Lawrence H.; Xu, Dongrong; Laine, Andrew F.; Liu, Jun; Peterson, Bradley S. (August 1, 2009). "Using Perturbation theory to reduce noise in diffusion tensor fields". Medical Image Analysis. 13 (4): 580–597. doi:10.1016/j.media.2009.05.001. PMC 2782748. PMID 19540791.
  56. ^ Zhu, Hongtu; Li, Yimei; Ibrahim, Joseph G.; Shi, Xiaoyan; An, Hongyu; Chen, Yashen; Gao, Wei; Lin, Weili; Rowe, Daniel B.; Peterson, Bradley S. (2009). "Regression Models for Identifying Noise Sources in Magnetic Resonance Images". Journal of the American Statistical Association. 104 (486): 623–637. doi:10.1198/jasa.2009.0029. PMC 2771876. PMID 19890478.
  57. ^ Duan, Yunsuo; Peterson, Bradley S.; Liu, Feng; Brown, Truman R.; Ibrahim, Tamer S.; Kangarlu, Alayar (January 12, 2009). "Computational and experimental optimization of a double-tuned 1 H/ 31 P four-ring birdcage head coil for MRS at 3T". Journal of Magnetic Resonance Imaging. 29 (1): 13–22. doi:10.1002/jmri.21509. PMID 19097097 – via CrossRef.
  58. ^ Xu, Dongrong; Hao, Xuejun; Wang, Zhishun; Duan, Yunsuo; Liu, Feng; Marsh, Rachel; Yu, Shan; Peterson, Bradley S. (June 12, 2012). "A Virtual Radial Arm Maze for the Study of Multiple Memory Systems in a Functional Magnetic Resonance Imaging Environment". The International Journal of Virtual Reality. 11 (2): 63–76. doi:10.20870/IJVR.2012.11.2.2844. PMC 4564131. PMID 26366052.
  59. ^ Bansal, Ravi; Staib, Lawrence H.; Laine, Andrew F.; Hao, Xuejun; Xu, Dongrong; Liu, Jun; Weissman, Myrna; Peterson, Bradley S. (December 7, 2012). "Anatomical Brain Images Alone Can Accurately Diagnose Chronic Neuropsychiatric Illnesses". PLOS ONE. 7 (12): e50698. Bibcode:2012PLoSO...750698B. doi:10.1371/journal.pone.0050698. PMC 3517530. PMID 23236384.
  60. ^ "Apparatus, method and computer-accessible medium for diagnosing and subtyping psychiatric diseases".
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