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Bimakalim

From Wikipedia, the free encyclopedia

Bimakalim
Names
Preferred IUPAC name
2,2-Dimethyl-4-(2-oxopyridin-1(2H)-yl)-2H-1-benzopyran-6-carbonitrile
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C17H14N2O2/c1-17(2)10-14(19-8-4-3-5-16(19)20)13-9-12(11-18)6-7-15(13)21-17/h3-10H,1-2H3
    Key: JTVSKASWNROQQF-UHFFFAOYSA-N
  • CC1(C=C(c2cc(ccc2O1)C#N)n3ccccc3=O)C
Properties
C17H14N2O2
Molar mass 278.311 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Bimakalim is a potassium channel opener.[1] It can be prepared from 2-acetyl-4-cyanophenol .[2]

References

  1. ^ Puddu, Paolo Emilio; Garlid, Keith D; Monti, Francesco; Iwashiro, Katsunori; Picard, Sandra; Dawodu, Amos Adeyemo; Criniti, Anna; Ruvolo, Giovanni; Campa, Pietro Paolo (2006). "Bimakalim: A Promising KATP Channel Activating Agent". Cardiovascular Drug Reviews. 18: 25. doi:10.1111/j.1527-3466.2000.tb00031.x.
  2. ^ Bergmann, Rolf; Gericke, Rolf (1990). "Synthesis and antihypertensive activity of 4-(1,2-dihydro-2-oxo-1-pyridyl)-2H-1-benzopyrans and related compounds, new potassium channel activators". Journal of Medicinal Chemistry. American Chemical Society (ACS). 33 (2): 492–504. doi:10.1021/jm00164a005. ISSN 0022-2623.
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This page was last edited on 12 November 2023, at 01:08
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