This family of proteins are found both in prokaryotes and eukaryotes. In mammals, they are transmembrane proteins with functions in the liver and in the intestine.[1] They are members of the solute carrier family of cotransporter genes which include SLC10A1 and SLC10A2.[1]
SLC10A1 encodes the sodium-taurocholate cotransporting polypeptide (NTCP) expressed in the liver and found on the basolateral membranes. It is involved in the uptake of all types of bile acids from portal blood plasma, a process mediated by the co-transport of Na+.[2] It is also capable of transporting other solutes and is necessary for the entry of hepatitis B and hepatitis D viruses into the hepatocyte.[3]
SLC10A2 encodes the apical sodium bile acid transporter (ASBT) expressed in the small intestine with highest concentrations in the ileum.[1] It is found on the brush border membrane and is also known as the ileal bile acid transporter (IBAT). It is responsible for the initial uptake of bile acids from the intestine as part of the enterohepatic circulation.[4] Inhibition of the intestinal bile acid:sodium cotransporter by elobixibat is under development for the treatment of constipation and irritable bowel syndrome.[5]
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Small Intestine Absorption
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Renal | Proximal Convoluted Tubule
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Reabsorption of filtrate from the PCT and hormones
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References
- ^ a b c Anwer MS, Stieger B (2014). "Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters". Pflügers Arch. 466 (1): 77–89. doi:10.1007/s00424-013-1367-0. PMC 3877701. PMID 24196564.
- ^ Hagenbuch B, Stieger B, Foguet M, Labbert H, Meier PJ (December 1991). "Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system". Proc. Natl. Acad. Sci. U.S.A. 88 (23): 10629–33. Bibcode:1991PNAS...8810629H. doi:10.1073/pnas.88.23.10629. PMC 52983. PMID 1961729.
- ^ Li W, Urban S (2016). "Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications". J. Hepatol. 64 (1 Suppl): S32–40. doi:10.1016/j.jhep.2016.02.011. PMC 7114860. PMID 27084034.
- ^ Dawson PA (2011). "Role of the intestinal bile acid transporters in bile acid and drug disposition". Drug Transporters. Handbook of Experimental Pharmacology. Vol. 201. pp. 169–203. doi:10.1007/978-3-642-14541-4_4. ISBN 978-3-642-14540-7. PMC 3249407. PMID 21103970.
- ^ Acosta A, Camilleri M (2014). "Elobixibat and its potential role in chronic idiopathic constipation". Therap Adv Gastroenterol. 7 (4): 167–75. doi:10.1177/1756283X14528269. PMC 4107709. PMID 25057297.
This page was last edited on 20 June 2023, at 20:40