To install click the Add extension button. That's it.
The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.
How to transfigure the Wikipedia
Would you like Wikipedia to always look as professional and up-to-date? We have created a browser extension. It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology.
Try it — you can delete it anytime.
Install in 5 seconds
Yep, but later
4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Bicuculline is a phthalide-isoquinoline compound that is a light-sensitive competitive antagonist of GABAA receptors.[1] It was originally identified in 1932 in plant alkaloid extracts[2] and has been isolated from Dicentra cucullaria, Adlumia fungosa, and several Corydalis species (all in subfamilyFumarioideae, previously known as family Fumariaceae). Since it blocks the inhibitory action of GABA receptors, the action of bicuculline mimics epilepsy; it also causes convulsions. This property is utilized in laboratories around the world in the in vitro study of epilepsy, generally in hippocampal or cortical neurons in prepared brain slices from rodents. This compound is also routinely used to isolate glutamatergic (excitatory amino acid) receptor function.
The action of bicuculline is primarily on the ionotropicGABAA receptors, which are ligand-gated ion channels concerned chiefly with the passing of chloride ions across the cell membrane, thus promoting an inhibitory influence on the target neuron. These receptors are the major targets for benzodiazepines, z-drugs, and related anxiolytic drugs.
The half-maximal inhibitory concentration (IC50) of bicuculline on GABAA receptors is 3 μM.[citation needed]
In addition to being a potent GABAA receptor antagonist, bicuculline can be used to block Ca2+-activated potassium channels.[3]
Sensitivity to bicuculline is defined by IUPHAR as a major criterion in the definition of GABAA receptors
YouTube Encyclopedic
1/5
Views:
10 243
2 858
7 570
4 322
7 895
Drugs Acting on GABA-A Receptor (Mechanisms)
How To Say Bicuculline
The GABAa Receptor & Positive Allosteric Modulation
How to Identify Dutchman's Breeches - Dicentra cucullaria
11. The neural control of visually guided eye movements 2
(what is this?) (verify)
This page was last edited on 11 April 2024, at 20:39