Transcription factor IIIB 50 kDa subunit

BRF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ROD, 4ROE, 4ROC
Identifiers
Aliases	BRF2, BRFU, TFIIIB50, RNA polymerase III transcription initiation factor 50 kDa subunit, RNA polymerase III transcription initiation factor subunit, BRF2 RNA polymerase III transcription initiation factor subunit
External IDs	OMIM: 607013 MGI: 1913903 HomoloGene: 10127 GeneCards: BRF2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 37,843,268 bp[1] End 37,849,861 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 27,613,392 bp[2] End 27,618,708 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle deltoid muscle gastrocnemius muscle quadriceps femoris muscle vastus lateralis muscle pancreatic ductal cell thymus spinal ganglia triceps brachii muscle prefrontal cortex Top expressed in spermatid spermatocyte secondary oocyte interventricular septum seminiferous tubule morula hand superior cervical ganglion superior frontal gyrus neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding RNA polymerase III type 3 promoter sequence-specific DNA binding transcription factor binding Cellular component nucleus nucleoplasm transcription factor TFIIIB complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase III cellular response to oxidative stress transcription preinitiation complex assembly DNA-templated transcription, initiation RNA polymerase III preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55290 66653 Ensembl ENSG00000104221 ENSMUSG00000031487 UniProt Q9HAW0 Q3UAW9 RefSeq (mRNA) NM_018310 NM_025686 RefSeq (protein) NP_060780 NP_079962 Location (UCSC) Chr 8: 37.84 – 37.85 Mb Chr 8: 27.61 – 27.62 Mb PubMed search [3] [4]
Wikidata
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Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene.^[5][6][7]

Function

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein.^[7]

References

Further reading

External links

• FactorBook BRF2

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 9 April 2022, at 01:27