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BD-1047

From Wikipedia, the free encyclopedia

BD-1047
Clinical data
ATC code
  • none
Identifiers
  • N'-[2-(3,4-dichlorophenyl)ethyl]-N,N,N'-trimethylethane-1,2-diamine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H20Cl2N2
Molar mass275.22 g·mol−1
3D model (JSmol)
  • Clc1ccc(CCN(C)CCN(C)C)cc1Cl
  • InChI=1S/C13H20Cl2N2/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11/h4-5,10H,6-9H2,1-3H3 checkY
  • Key:MGVRNMUKTZOQOW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

BD-1047 is a sigma receptor antagonist, selective for the σ1 subtype. It has effects in animal studies suggestive of antipsychotic activity and may also be useful in the treatment of neuropathic pain.[1][2]

More recent studies also suggest a novel role for BD-1047 in attenuating ethanol-induced neurotoxicity in vitro, and additional research is being conducted on this compound as a possible pharmacotherapy for alcohol use disorder (AUD) [3]

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Transcription

References

  1. ^ Skuza G, Rogóz Z (2006). "Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity". Pharmacological Reports. 58 (5): 626–35. PMID 17085854.
  2. ^ Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH (November 2008). "Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain". Anesthesiology. 109 (5): 879–89. doi:10.1097/ALN.0b013e3181895a83. PMID 18946301.
  3. ^ Reynolds AR, Saunders MA, Prendergast MA (2016). "Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3". Alcohol Clin Exp Res. 40 (7): 1454–61. doi:10.1111/acer.13097. PMC 6662182. PMID 27177604.


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This page was last edited on 16 January 2024, at 11:55
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