Andrew McKenzie | |
|---|---|
 Andrew McKenzie at the Royal Society admissions day in London, July 2017 | |
| Born | Andrew Neil James McKenzie |
| Education | University of London (PhD) |
| Spouse | Sarah Bell |
| Children | James Mckenzie, Ross Mckenzie |
| Scientific career | |
| Fields | Immunology Autoimmunity Molecular biology |
| Institutions | Laboratory of Molecular Biology University of Cambridge National Institute for Medical Research[1] |
| Thesis | Cellular and humoral aspects of the immune response of the larval stages of Calliphora vomitoria L. (Insecta: Diptera) (1988) |
| Website | www2 |
Andrew Neil James McKenzie FRS FMedSci[2] is a molecular biologist and group leader in the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB).[3]
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Transcription
Education
McKenzie was educated at the University of London where he was awarded a PhD for research on the immune response of the bluebottle fly (Calliphora vomitoria),[4] covering both humoral immunity and cell-mediated immunity.
Research and career
McKenzie's research investigates how the innate immune system and adaptive immune system protect the body from infection, but can also lead to inflammation and pathology.[2] He has defined and characterised how biological networks orchestrate responses to pathogens and how dysregulation of these biological pathways can lead to diseases such as asthma and allergy.[2][5]
His identification of the cytokine Interleukin 13 and the subsequent unearthing of its central role in allergic asthma led to his discovery of type-2 innate lymphoid cells (ILC2).[6][7] These cells secrete large quantities of cytokines and represent a new druggable biological target for intervention in inflammation and infection.[2]
Awards and honours
McKenzie was elected a Fellow of the Royal Society (FRS) in 2017[2] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2011.[8]
References
- ^ McKenzie, Andrew N.J.; Ely, Barry; Sanderson, Colin J. (1991). "Mutated interleukin-5 monomers are biologically inactive". Molecular Immunology. 28 (1–2): 155–158. doi:10.1016/0161-5890(91)90099-6. ISSN 0161-5890. PMID 1901378.
- ^ a b c d e Anon (2017). "Dr Andrew McKenzie FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 2017-05-05. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Terms, conditions and policies | Royal Society". Archived from the original on 2016-11-11. Retrieved 2017-08-18.
{{cite web}}: CS1 maint: bot: original URL status unknown (link) - ^ Andrew N. J. McKenzie publications indexed by the Scopus bibliographic database. (subscription required)
- ^ McKenzie, Andrew Neil James (1988). Cellular and humoral aspects of the immune response of the larval stages of Calliphora vomitoria L. (Insecta: Diptera). london.ac.uk (PhD thesis). University of London. OCLC 940318709.
- ^ Neill, Daniel R.; Wong, See Heng; Bellosi, Agustin; Flynn, Robin J.; Daly, Maria; Langford, Theresa K. A.; Bucks, Christine; Kane, Colleen M.; Fallon, Padraic G.; Pannell, Richard; Jolin, Helen E.; McKenzie, Andrew N. J. (2010). "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity". Nature. 464 (7293): 1367–1370. doi:10.1038/nature08900. ISSN 0028-0836. PMC 2862165. PMID 20200518.
- ^ Spits, Hergen; Artis, David; Colonna, Marco; Diefenbach, Andreas; Di Santo, James P.; Eberl, Gerard; Koyasu, Shigeo; Locksley, Richard M.; McKenzie, Andrew N. J.; Mebius, Reina E.; Powrie, Fiona; Vivier, Eric (2013). "Innate lymphoid cells — a proposal for uniform nomenclature". Nature Reviews Immunology. 13 (2): 145–149. doi:10.1038/nri3365. ISSN 1474-1733. PMID 23348417. (subscription required)
- ^ Newland, Stephen A.; Mohanta, Sarajo; Clément, Marc; Taleb, Soraya; Walker, Jennifer A.; Nus, Meritxell; Sage, Andrew P.; Yin, Changjun; Hu, Desheng; Kitt, Lauren L.; Finigan, Alison J.; Rodewald, Hans-Reimer; Binder, Christoph J.; McKenzie, Andrew N. J.; Habenicht, Andreas J.; Mallat, Ziad (2017). "Type-2 innate lymphoid cells control the development of atherosclerosis in mice". Nature Communications. 8: 15781. doi:10.1038/ncomms15781. ISSN 2041-1723. PMC 5467269. PMID 28589929.
- ^ "Andrew McKenzie". Retrieved 22 January 2022.
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This page was last edited on 24 August 2022, at 05:33