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From Wikipedia, the free encyclopedia

ATNAA
Combination of
AtropineAnticholinergic agent
Pralidoxime chlorideAntidote
Clinical data
Trade namesAtnaa, Duodote
AHFS/Drugs.comProfessional Drug Facts
License data
Routes of
administration
Intramuscular
ATC code
Legal status
Legal status
Identifiers
KEGG

An ATNAA (Antidote Treatment Nerve Agent Autoinjector) is any of a variety of autoinjectors in use with the US Armed Forces. An autoinjector is a medical device designed to deliver a single dose of a particular (typically life-saving) drug.

Most autoinjectors are spring-loaded syringes. By design, autoinjectors are easy to use and are intended for self-administration by patients. The site of injection depends on the drug loaded, but it typically is administered into the thigh or the buttocks. The injectors were initially designed to overcome the hesitation associated with self-administration of the needle-based drug delivery device. It is the newer delivery vehicle to be used in lieu of the Mark I NAAK.

Purpose

The ATNAA provides atropine and pralidoxime chloride in a single delivery system, although the two drugs are separate within the device.[1][2] The use of the device is only to be administered in the extreme case of organophosphate poisoning. The delivery system is designed for use by military personnel only, and is only issued to DOD personnel that are considered to be in immediate danger of a chemical attack or work in a position (such as ordnance disposal) where there is a high likelihood of nerve agent exposure.[3]

FDA approval

During initial trials and submission to the FDA for approval, the United States Department of Defense requested that the Food and Drug Administration (FDA) waive the requirement for the phrase 'Rx only' being included on the labeling for the ATNAA device; the rationale being that it would be confusing to troops. The waiver request was denied. The DoD opted to include the phrase at the end of the package insert instead, and this modification was found acceptable.[4]

Training

As a condition of approval, the FDA lists on the device label the precise instructions that are to be given to military personnel on dosage and administration.[1][2] While each branch of the DoD typically provides their own tailored training, an example of the MK I NAAK and ATNAA are referenced in the United States Air Force Self Aid Buddy Care Training (SABC). SABC encompasses basic life support and limb-saving techniques to help wounded or injured personnel survive in medical emergencies until medical help is available.[5]

References

  1. ^ a b c "Atnaa atropine and pralidoxime chloride auto-injector- atropine and pralidoxime chloride kit". DailyMed. 22 March 2017. Retrieved 27 May 2020.
  2. ^ a b c "Duodote- atropine and pralidoxime chloride kit". DailyMed. 22 October 2018. Retrieved 27 May 2020.
  3. ^ "Drug Approval Package: ATNAA Injection in an (Atropine/Pralidoxime) Autoinjector NDA #21-175". U.S. Food and Drug Administration (FDA). 18 January 2006. Retrieved 26 December 2023.
  4. ^ "Clinical Pharmacology and Biopharmaceutical Review" (PDF). Center for Drug Evaluation and Research. U.S. Food and Drug Administration. p. 59. Archived from the original (PDF) on 22 October 2008. Retrieved 13 May 2009.
  5. ^ "Training Objectives AFI 36-2238, SABC Training" (PDF). Archived from the original (PDF) on 15 February 2010.

Further reading

  • Landauer W (February 1977). "Cholinomimetic teratogens. V. The effect of oximes and related cholinesterase reactivators". Teratology. 15 (1): 33–42. doi:10.1002/tera.1420150105. PMID 320703.
  • Moller KO, Jensen-Holm J, Lausen HH (April 1961). "HH L. Treatment of acute phosphostigmine poisoning". Ugeskrift for Laeger. 123: 501–5. PMID 13771863.
  • Namba T, Nolte CT, Jackrel J, Grob D (April 1971). "Poisoning due to organophosphate insecticides. Acute and chronic manifestations". The American Journal of Medicine. 50 (4): 475–92. doi:10.1016/0002-9343(71)90337-8. PMID 4324629.
  • Arena JM (1974). Poisoning. Toxicology, symptoms, treatments (4th ed.). Springfield, IL: Charles C. Thomas. p. 133.
  • Brachfeld J, Zavon MR (December 1965). "Organic phosphate (phosdrin) intoxication. Report of a case and the results of treatment with 2-PAM". Archives of Environmental Health. 11 (6): 859–62. doi:10.1080/00039896.1965.10664314. PMID 5846083.
  • Hayes Jr WJ (1975). Toxicology of Pesticides. Baltimore: The Williams & Wilkins Company. p. 416.
This page was last edited on 23 January 2024, at 07:35
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