API5

API5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3U0R, 3V6A

Identifiers

Aliases

API5, AAC-11, AAC11, apoptosis inhibitor 5

External IDs

OMIM: 609774 MGI: 1888993 HomoloGene: 4809 GeneCards: API5

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11p12	Start	43,311,963 bp^[1]
Band	11p12	End	43,344,529 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 E1	Start	94,242,027 bp^[2]
Band	2\|2 E1	End	94,268,481 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

rectum

superficial temporal artery

oocyte

parotid gland

endometrium

ganglionic eminence

cecum

appendix

human penis

Top expressed in

primitive streak

cumulus cell

external carotid artery

maxillary prominence

retinal pigment epithelium

ureter

ciliary body

lacrimal gland

internal carotid artery

conjunctival fornix

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	fibroblast growth factor binding protein binding RNA binding
Cellular component	cytoplasm spliceosomal complex membrane nucleus nuclear speck
Biological process	negative regulation of fibroblast apoptotic process negative regulation of apoptotic process apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8539


11800

Ensembl


ENSG00000166181


ENSMUSG00000027193

UniProt


Q9BZZ5


O35841

RefSeq (mRNA)


NM_001142930 NM_001142931 NM_001243747 NM_006595


NM_007466 NM_001305258 NM_001349003

RefSeq (protein)


NP_001136402 NP_001136403 NP_001230676 NP_006586


NP_001292187 NP_031492 NP_001335932

Location (UCSC)

Chr 11: 43.31 – 43.34 Mb

Chr 2: 94.24 – 94.27 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

The human gene API5 encodes the protein Apoptosis inhibitor 5.^[5]^[6]

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction ^[7]

Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.

API5 functions in nuclear export of mRNA.^[8]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (September 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Research. 57 (18): 4063–9. PMID 9307294.
^ "Entrez Gene: API5 apoptosis inhibitor 5".
^ Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI (March 2012). "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules". The Journal of Biological Chemistry. 287 (14): 10727–37. doi:10.1074/jbc.M111.317594. PMC 3322819. PMID 22334682.
^ Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI (2020). "Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction". Nucleic Acids Res. 48 (11): 6340–6352. doi:10.1093/nar/gkaa335. PMC 7293033. PMID 32383752.

Gianfrancesco F, Esposito T, Ciccodicola A, D'Esposito M, Mazzarella R, D'Urso M, Forabosco A (1999). "Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene". Cytogenetics and Cell Genetics. 84 (3–4): 164–6. doi:10.1159/000015247. PMID 10393420. S2CID 44601647.
Kim JW, Cho HS, Kim JH, Hur SY, Kim TE, Lee JM, Kim IK, Namkoong SE (April 2000). "AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis". Laboratory Investigation; A Journal of Technical Methods and Pathology. 80 (4): 587–94. doi:10.1038/labinvest.3780008. PMID 10780674.
Van den Berghe L, Laurell H, Huez I, Zanibellato C, Prats H, Bugler B (November 2000). "FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2". Molecular Endocrinology. 14 (11): 1709–24. doi:10.1210/me.14.11.1709. PMID 11075807.
Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire G, Cáceres JF, Bickmore WA (September 2001). "Large-scale identification of mammalian proteins localized to nuclear sub-compartments". Human Molecular Genetics. 10 (18): 1995–2011. doi:10.1093/hmg/10.18.1995. PMID 11555636.
Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (April 2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". AI Zheng = Aizheng = Chinese Journal of Cancer. 22 (4): 380–4. PMID 12703993.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". Journal of Proteome Research. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Morris EJ, Michaud WA, Ji JY, Moon NS, Rocco JW, Dyson NJ (November 2006). "Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo". PLOS Genetics. 2 (11): e196. doi:10.1371/journal.pgen.0020196. PMC 1636698. PMID 17112319.
Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI (2012). "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules". J Biol Chem. 287 (14): 10727–37. doi:10.1074/jbc.M111.317594. PMC 3322819. PMID 22334682.
Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI (2020). "Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction". Nucleic Acids Res. 48 (11): 6340–6352. doi:10.1093/nar/gkaa335. PMC 7293033. PMID 32383752.

This page was last edited on 1 December 2023, at 03:07

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