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AL-38022A

From Wikipedia, the free encyclopedia

AL-38022A
Identifiers
  • (S)-2-(8,9-Dihydro-7H'-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H17N3O
Molar mass231.299 g·mol−1
3D model (JSmol)
Melting point106 to 107 °C (223 to 225 °F)
  • c13CCCOc3ccc(cn2)c1n2CC(C)N
  • InChI=1S/C13H17N3O/c1-9(14)8-16-13-10(7-15-16)4-5-12-11(13)3-2-6-17-12/h4-5,7,9H,2-3,6,8,14H2,1H3/t9-/m0/s1 checkY
  • Key:FJRIVFVALIEIOY-VIFPVBQESA-N checkY
 ☒NcheckY (what is this?)  (verify)

AL-38022A is an indazole derivative drug which is one of a range of similar drugs developed for scientific research and with some possible clinical applications. It acts as a potent and selective agonist for the 5-HT2 family of serotonin receptors, with highest binding affinity for the 5-HT2C subtype and around four times less affinity for 5-HT2A and 5-HT2B. In drug discrimination tests on animals, it fully substituted for both DOM and 5-MeO-DMT.[1]

See also

References

  1. ^ May JA, Sharif NA, Chen HH, Liao JC, Kelly CR, Glennon RA, et al. (January 2009). "Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]". Pharmacology, Biochemistry, and Behavior. 91 (3): 307–14. doi:10.1016/j.pbb.2008.07.015. PMC 3763814. PMID 18718483.


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This page was last edited on 21 March 2024, at 14:59
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