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AF-353

From Wikipedia, the free encyclopedia

AF-353
Identifiers
  • 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H17IN4O2
Molar mass400.220 g·mol−1
3D model (JSmol)
  • CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC
  • InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19)
  • Key:AATPYXMXFBBKFO-UHFFFAOYSA-N

AF-353 is a drug which acts as an antagonist of the P2X3 homotrimeric and P2X2/3 heterotrimeric forms of the P2X purinoreceptors. It has been found to block taste responses and has been proposed as an agent for masking the bitter taste of medications.[1][2][3]

See also

References

  1. ^ Gever JR, Soto R, Henningsen RA, Martin RS, Hackos DH, Panicker S, et al. (July 2010). "AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist". British Journal of Pharmacology. 160 (6): 1387–1398. doi:10.1111/j.1476-5381.2010.00796.x. PMC 2938810. PMID 20590629.
  2. ^ Vandenbeuch A, Larson ED, Anderson CB, Smith SA, Ford AP, Finger TE, et al. (March 2015). "Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice". The Journal of Physiology. 593 (5): 1113–1125. doi:10.1113/jphysiol.2014.281014. PMC 4358674. PMID 25524179.
  3. ^ Flammer LJ, Ellis H, Rivers N, Caronia L, Ghidewon MY, Christensen CM, et al. (May 2024). "Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities". British Journal of Pharmacology. doi:10.1111/bph.16411. PMID 38745397.


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This page was last edited on 26 June 2024, at 16:46
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