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From Wikipedia, the free encyclopedia

ADAM33
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADAM33, C20orf153, DJ964F7.1, ADAM metallopeptidase domain 33
External IDsOMIM: 607114 MGI: 1341813 HomoloGene: 11881 GeneCards: ADAM33
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282447
NM_025220
NM_153202

NM_001163529
NM_033615

RefSeq (protein)

NP_001269376
NP_079496
NP_694882

NP_001157001
NP_291093

Location (UCSC)Chr 20: 3.67 – 3.68 MbChr 2: 130.89 – 130.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.[5][6]

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Transcription

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness.[7] Alternative splicing of this gene results in two transcript variants encoding different isoforms.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149451 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027318 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S (January 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–36. doi:10.1016/S0378-1119(01)00818-6. PMID 11814695.
  6. ^ a b "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33".
  7. ^ Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM (2016-07-21). "Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life". JCI Insight. 1 (11). doi:10.1172/jci.insight.87632. ISSN 0021-9738. PMC 4968941. PMID 27489884.

Further reading

External links


This page was last edited on 26 January 2024, at 10:46
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