ABCC13

ABCC13

Identifiers

ABCC13, C21orf73, PRED6, ABCC13P, ATP binding cassette subfamily C member 13 (pseudogene)

External IDs

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q11.2	Start	14,236,206 bp^[1]
Band	21q11.2	End	14,362,754 bp^[1]

Orthologs

Species

Human

Mouse

Entrez


150000


n/a

Ensembl


ENSG00000243064


n/a

UniProt


n a


n/a

RefSeq (mRNA)


NM_138726 NM_172024 NM_172025 NM_172026


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 21: 14.24 – 14.36 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Putative ATP-binding cassette transporter sub-family C member 13 is a protein that is not present in humans. In humans, ABCC13 is a pseudogene.^[3]

Function

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243064 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "ABCC13 ATP binding cassette subfamily C member 13 (pseudogene) [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 11 August 2019.

Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates". Annual Review of Genomics and Human Genetics. 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856.
Annilo T, Dean M (Jul 2004). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages". Genomics. 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Brun ME, Ruault M, Ventura M, Roizès G, De Sario A (Jul 2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms". Gene. 312: 41–50. doi:10.1016/S0378-1119(03)00530-4. PMID 12909339.
Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T (Dec 2002). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver". Biochemical and Biophysical Research Communications. 299 (3): 410–7. doi:10.1016/S0006-291X(02)02658-X. PMID 12445816.
Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Membrane proteins, carrier proteins: membrane transport proteins ABC-transporter (TC 3A1)
A	A1 A2 A3 A4 A7 A8 A12 A13
B	B1 B2-3 (B2 B3) B4 B5 B6 B7 B9 B11
C	C1 C2 C3 C4 C5 C6 C7 C8-9 (C8, C9) C10 C11 C13
D	D1 D2 D3 D4
E	E1
F	F1 F2
G	G1 G2 G4 Sterolin (G5, G8)
see also ABC transporter disorders

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This page was last edited on 28 November 2023, at 02:54

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Function

See also

References

Further reading