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Isoamyl alcohol

From Wikipedia, the free encyclopedia

Isoamyl alcohol[1]
Names
Preferred IUPAC name
3-Methylbutan-1-ol
Other names
3-Methyl-1-butanol
Isopentyl alcohol
Isopentanol
Isobutylcarbinol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.004.213 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C5H12O/c1-5(2)3-4-6/h5-6H,3-4H2,1-2H3 checkY
    Key: PHTQWCKDNZKARW-UHFFFAOYSA-N checkY
  • InChI=1/C5H12O/c1-5(2)3-4-6/h5-6H,3-4H2,1-2H3
    Key: PHTQWCKDNZKARW-UHFFFAOYAW
  • OCCC(C)C
Properties
C5H12O
Molar mass 88.148 g/mol
Appearance Clear, colorless liquid
Odor Disagreeable odor in high concentrations
Density 0.8104 g/cm3 at 20 °C
Melting point −117[2][3] °C (−179 °F; 156 K)
Boiling point 131.1 °C (268.0 °F; 404.2 K)
Slightly soluble, 28 g/L
Solubility Very soluble in acetone, diethyl ether, ethanol
Vapor pressure 28 mmHg (20 °C)[3]
−68.96·10−6 cm3/mol
Viscosity 3.692 mPa·s
Thermochemistry
2.382 J/g·K
−356.4 kJ/mol (liquid)
−300.7 kJ/mol (gas)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Flammable, moderately toxic
GHS labelling:
Flammable
Corrosive
Irritant
Danger
H226, H302, H305, H315, H318, H332, H335
P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, P501
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineFlammability 2: Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur. Flash point between 38 and 93 °C (100 and 200 °F). E.g. diesel fuelInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
2
0
Flash point 43 °C (109 °F; 316 K)
350 °C (662 °F; 623 K)
Explosive limits 1.2–9%
Lethal dose or concentration (LD, LC):
1453 mg/kg (rabbit, oral)
1300 mg/kg (rat, oral)[4]
NIOSH (US health exposure limits):
PEL (Permissible)
 TWA 100 ppm (360 mg/m3)[3]
REL (Recommended)
 TWA 100 ppm (360 mg/m3), ST 125 ppm (450 mg/m3)[3]
IDLH (Immediate danger)
 500 ppm[3]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Isoamyl alcohol is a colorless liquid with the formula C
5H
12O, specifically (H3C–)2CH–CH2–CH2–OH. It is one of several isomers of amyl alcohol (pentanol). It is also known as isopentyl alcohol, isopentanol, or (in the IUPAC recommended nomenclature) 3-methyl-butan-1-ol. An obsolete name for it was isobutyl carbinol.[5]

Isoamyl alcohol is an ingredient in the production of banana oil, an ester found in nature and also produced as a flavouring in industry. It is a common fusel alcohol, produced as a major by-product of ethanol fermentation.

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Transcription

Occurrence

Isoamyl alcohol is one of the components of the aroma of Tuber melanosporum, the black truffle.

Fusel alcohols like isoamyl alcohol are grain fermentation byproducts, and therefore trace amounts of isoamyl are present in many alcoholic beverages.

The compound has also been identified as a chemical in the pheromone used by hornets to attract other members of the hive to attack.[6]

Extraction from fusel oil

Isoamyl alcohol can be separated from fusel oil by either of two methods: shaking with strong brine solution and separating the oily layer from the brine layer; distilling it and collecting the fraction that boils between 125 and 140 °C. Further purification is possible with this procedure: shaking the product with hot limewater, separating the oily layer, drying the product with calcium chloride, and distilling it, collecting the fraction boiling between 128 and 132 °C.[5]

Synthesis

Isoamyl alcohol can be synthesized by condensation of isobutene and formaldehyde which produces isoprenol and hydrogenation. It is a colourless liquid of density 0.8247 g/cm3 (0 °C), boiling at 131.6 °C, slightly soluble in water, and easily dissolved in organic solvents. It has a characteristic strong smell and a sharp burning taste. On passing the vapour through a red-hot tube, it decomposes into acetylene, ethylene, propylene, and other compounds. It is oxidized by chromic acid to isovaleraldehyde, and it forms addition compounds crystals with calcium chloride and tin(IV) chloride.[5]

Uses

Besides its use in the synthesis of banana oil, isoamyl alcohol is also an ingredient of Kovac's reagent, used for the bacterial diagnostic indole test.

It is also used as an antifoaming agent in the chloroform isoamyl alcohol reagent.[7]

Isoamyl alcohol is used in a phenol–chloroform extraction mixed with the chloroform to further inhibit RNase activity and prevent solubility of RNAs with long tracts of poly-adenine.[8]

Drugs

IAA is also used as the reactant in the synthesis of the following list of drugs:

  1. Amixetrine
  2. Amoproxan
  3. Camylofin
  4. Fenetradil

References

  1. ^ Lide, David R., ed. (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, Florida: CRC Press. pp. 3–374, 5–42, 6–188, 8–102, 15–22. ISBN 0-8493-0487-3.
  2. ^ Straka, M.; van Genderen, A.; Růžička, K.; Růžička, V. Heat Capacities in the Solid and in the Liquid Phase of Isomeric Pentanols. J. Chem. Eng. Data 2007, 52, 794-802.
  3. ^ a b c d e NIOSH Pocket Guide to Chemical Hazards. "#0348". National Institute for Occupational Safety and Health (NIOSH).
  4. ^ "Isoamyl alcohol". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  5. ^ a b c  One or more of the preceding sentences incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). "Amyl Alcohols". Encyclopædia Britannica. Vol. 1 (11th ed.). Cambridge University Press. p. 900.
  6. ^ Wilson, Calum & Davies, Noel & Corkrey, Ross & J. Wilson, Annabel & M. Mathews, Alison & C. Westmore, Guy. (2017). Receiver Operating Characteristic curve analysis determines association of individual potato foliage volatiles with onion thrips preference, cultivar and plant age. PLOS ONE. 12. e0181831. 10.1371/journal.pone.0181831.
  7. ^ Zumbo, P. "Phenol-chloroform Extraction" (PDF). WEILL CORNELL MEDICAL COLLEGE P. ZUMBO LABORATORY OF CHRISTOPHER E. MASON, PH.D. Retrieved 19 June 2014.
  8. ^ Green, Michael; Sambrook, Joseph. "Purification of Nucleic Acids: Extraction with Phenol-Chloroform". Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press. ISBN 1936113422.

This page was last edited on 24 March 2024, at 14:12
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