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2-Octyl cyanoacrylate

From Wikipedia, the free encyclopedia

Not to be confused with Octyl cyanoacrylate.
2-Octyl cyanoacrylate
Names
Preferred IUPAC name
Octan-2-yl 2-cyanoprop-2-enoate
Other names
2-Octyl 2-cyanoacrylate; 1-Methylheptyl cyanoacrylate
Identifiers
3D model (JSmol)
11343617
ChemSpider
DrugBank
ECHA InfoCard 100.223.166 Edit this at Wikidata
EC Number
  • 700-845-1
UNII
  • InChI=1S/C12H19NO2/c1-4-5-6-7-8-11(3)15-12(14)10(2)9-13/h11H,2,4-8H2,1,3H3 ☒N
    Key: CQVWXNBVRLKXPE-UHFFFAOYSA-N ☒N
  • InChI=1/C12H19NO2/c1-4-5-6-7-8-11(3)15-12(14)10(2)9-13/h11H,2,4-8H2,1,3H3
    Key: CQVWXNBVRLKXPE-UHFFFAOYAO
  • C=C(C#N)C(OC(C)CCCCCC)=O
Properties
C12H19NO2
Molar mass 209.289 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

2-Octyl cyanoacrylate is a cyanoacrylate ester typically used as a wound closure adhesive (under the brand name Dermabond).[1] It is closely related to octyl cyanoacrylate. The use of 2-octyl cyanoacrylate was approved in 1998; offered as an alternative to stitches, sutures, and or adhesive strips.[2]

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Transcription

Adhesion mechanism

When the 2-octyl cyanoacrylate monomers are exposed to anions, provided either by moisture from the skin or exudate they quickly polymerize causing an exothermic reaction binding to the most superficial layer of epithelium. The seal formed by the cyanoacrylate is water tight allowing for the wound to heal uninterrupted.[2]

Anti-microbial properties

Anti-microbial properties have been observed against gram-positive and non-pseudomonas gram-negative bacteria, but are not fully understood. it is believed that the interaction between the positively charged bacterial capsule and the negatively charged 8-octyl cyanoacrylate destabilizes the cell capsule of the bacteria, killing it. [2]

References

  1. ^ "Summary of Safety and Effectiveness Data" (PDF). Food and Drug Administration. 1998.
  2. ^ a b c Perera, AG Nuwan; Tavarez, Melissa M. (2022), "2-Octyl Cyanoacrylate", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 30335326, retrieved 2022-08-19

See also

This page was last edited on 27 March 2024, at 14:53
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