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Zinc finger, FYVE domain containing 26 is a protein that in humans is encoded by the ZFYVE26 gene.[5]
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Transcription
Function
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.[5]
Elleuch N, Bouslam N, Hanein S, Lossos A, Hamri A, Klebe S, Meiner V, Birouk N, Lerer I, Grid D, Bacq D, Tazir M, Zelenika D, Argov Z, Durr A, Yahyaoui M, Benomar A, Brice A, Stevanin G (Nov 2007). "Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families". Neurogenetics. 8 (4): 307–15. doi:10.1007/s10048-007-0097-x. PMID17661097. S2CID25209385.
Goizet C, Boukhris A, Maltete D, Guyant-Maréchal L, Truchetto J, Mundwiller E, Hanein S, Jonveaux P, Roelens F, Loureiro J, Godet E, Forlani S, Melki J, Auer-Grumbach M, Fernandez JC, Martin-Hardy P, Sibon I, Sole G, Orignac I, Mhiri C, Coutinho P, Durr A, Brice A, Stevanin G (Oct 2009). "SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum". Neurology. 73 (14): 1111–9. doi:10.1212/WNL.0b013e3181bacf59. PMID19805727. S2CID39444163.
Murmu RP, Martin E, Rastetter A, Esteves T, Muriel MP, El Hachimi KH, Denora PS, Dauphin A, Fernandez JC, Duyckaerts C, Brice A, Darios F, Stevanin G (Jul 2011). "Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia". Molecular and Cellular Neurosciences. 47 (3): 191–202. doi:10.1016/j.mcn.2011.04.004. PMID21545838. S2CID5450391.
Hughes CA, Byrne PC, Webb S, McMonagle P, Patterson V, Hutchinson M, Parfrey NA (May 2001). "SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q". Neurology. 56 (9): 1230–3. doi:10.1212/wnl.56.9.1230. PMID11342696. S2CID31185837.