To install click the Add extension button. That's it.
The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.
How to transfigure the Wikipedia
Would you like Wikipedia to always look as professional and up-to-date? We have created a browser extension. It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology.
Try it — you can delete it anytime.
Install in 5 seconds
Yep, but later
4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1gene.[5] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.[6][7][8]
Function
WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[5]
Reguart N, He B, Xu Z, et al. (2004). "Cloning and characterization of the promoter of human Wnt inhibitory factor-1". Biochem. Biophys. Res. Commun. 323 (1): 229–34. doi:10.1016/j.bbrc.2004.08.075. PMID15351726.
Esufali S, Bapat B (2004). "Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation". Oncogene. 23 (50): 8260–71. doi:10.1038/sj.onc.1208007. PMID15377999. S2CID30877665.
Ohigashi T, Mizuno R, Nakashima J, et al. (2005). "Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells". Prostate. 62 (1): 61–8. doi:10.1002/pros.20117. PMID15389810. S2CID1398615.
Lin YC, You L, Xu Z, et al. (2006). "Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines". Biochem. Biophys. Res. Commun. 341 (2): 635–40. doi:10.1016/j.bbrc.2005.12.220. PMID16427602.
Urakami S, Shiina H, Enokida H, et al. (2006). "Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway". Clin. Cancer Res. 12 (2): 383–91. doi:10.1158/1078-0432.CCR-05-1344. PMID16428476. S2CID22202251.
Liepinsh E, Bányai L, Patthy L, Otting G (2006). "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1". J. Mol. Biol. 357 (3): 942–50. doi:10.1016/j.jmb.2006.01.047. PMID16476441.
Batra S, Shi Y, Kuchenbecker KM, et al. (2006). "Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma". Biochem. Biophys. Res. Commun. 342 (4): 1228–32. doi:10.1016/j.bbrc.2006.02.084. PMID16516163.
Queimado L, Lopes CS, Reis AM (2007). "WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors". Genes Chromosomes Cancer. 46 (3): 215–25. doi:10.1002/gcc.20402. PMID17171686. S2CID34184943.