Tweety family member 2

TTYH2

Identifiers

TTYH2, C17orf29, Tweety family member 2

External IDs

OMIM: 608855; MGI: 2157091; HomoloGene: 41882; GeneCards: TTYH2; OMA:TTYH2 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q25.1	Start	74,213,571 bp^[1]
Band	17q25.1	End	74,262,020 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E2	Start	114,566,257 bp^[2]
Band	11\|11 E2	End	114,611,803 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

inferior ganglion of vagus nerve

external globus pallidus

corpus callosum

subthalamic nucleus

medulla oblongata

ventral tegmental area

pons

superior vestibular nucleus

endothelial cell

spinal cord

Top expressed in

left lobe of liver

internal carotid artery

external carotid artery

intestinal villus

motor neuron

blastocyst

duodenum

jejunum

pineal gland

knee joint

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding chloride channel activity intracellular calcium activated chloride channel activity volume-sensitive chloride channel activity
Cellular component	integral component of membrane plasma membrane membrane chloride channel complex
Biological process	chloride transport chloride transmembrane transport ion transport ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


94015


117160

Ensembl


ENSG00000141540


ENSMUSG00000034714

UniProt


Q9BSA4


Q3TH73

RefSeq (mRNA)


NM_032646 NM_052869 NM_001330453


NM_053273

RefSeq (protein)


NP_001317382 NP_116035 NP_443101


NP_444503

Location (UCSC)

Chr 17: 74.21 – 74.26 Mb

Chr 11: 114.57 – 114.61 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene.^[5] Members of this family function as chloride channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene.

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141540 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034714 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tweety family member 2".

Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T (June 2011). "Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor". Nature Biotechnology. 29 (7): 653–8. doi:10.1038/nbt.1905. PMID 21706016. S2CID 205275786.
Ibarrola N, Molina H, Iwahori A, Pandey A (April 2004). "A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine". The Journal of Biological Chemistry. 279 (16): 15805–13. doi:10.1074/jbc.M311714200. PMID 14739304.
Rae FK, Hooper JD, Eyre HJ, Sutherland GR, Nicol DL, Clements JA (October 2001). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma". Genomics. 77 (3): 200–7. doi:10.1006/geno.2001.6629. PMID 11597145.
Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M (May 2007). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation". World Journal of Gastroenterology. 13 (19): 2717–21. doi:10.3748/wjg.v13.i19.2717. PMC 4147121. PMID 17569141.
Suzuki M, Mizuno A (May 2004). "A novel human Cl(-) channel family related to Drosophila flightless locus". The Journal of Biological Chemistry. 279 (21): 22461–8. doi:10.1074/jbc.M313813200. PMID 15010458.
He Y, Ramsay AJ, Hunt ML, Whitbread AK, Myers SA, Hooper JD (May 2008). "N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)". The Biochemical Journal. 412 (1): 45–55. doi:10.1042/BJ20071722. PMID 18260827. S2CID 25166381.
He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD (August 2008). "The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels". The Journal of Biological Chemistry. 283 (35): 24000–10. doi:10.1074/jbc.M803361200. PMC 3259790. PMID 18577513.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 26 October 2023, at 03:01

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