Thymic hypoplasia

Thymic hypoplasia
Specialty	Medical genetics

Thymic hypoplasia is a condition where the thymus is underdeveloped or involuted.

Causes

There are various causes of thymic hypoplasia such as 22q11.2 deletion syndrome, CHARGE syndrome, Nude/SCID and otofaciocervical syndrome type 2 (OTFCS2),^[1] and ataxia telangiectasia.^[2]

^ Bhalla P, Wysocki CA, van Oers NS (May 2020). "Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models". Frontiers in Immunology. 11: 830. doi:10.3389/fimmu.2020.00830. PMC 7214791. PMID 32431714.
^ Taylor AM, Hernandez D, McConville CM, Woods CG, Stacey M, Biggs P, Byrd PJ, Arlett CF, Scott D (1996). "Malignant disease and variations in radiosensitivity in ataxia telangiectasia patients.". Genetic predisposition to cancer 1996. Boston, MA: Springer. pp. 138–151. doi:10.1007/978-1-4899-4501-3_9. ISBN 978-0-412-56580-9.

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v t e Lymphatic disease: organ and vessel diseases
Thymus	Abscess Hyperplasia Hypoplasia DiGeorge syndrome Ectopic thymus Thymoma Thymic carcinoma
Spleen	Asplenia Asplenia with cardiovascular anomalies Accessory spleen Polysplenia Wandering spleen Splenomegaly Banti's syndrome Splenic infarction Splenic tumor
Lymph node	Lymphadenopathy Generalized lymphadenopathy Castleman's disease Intranodal palisaded myofibroblastoma Kikuchi disease Tonsils see Template:Respiratory pathology
Lymphatic vessels	Lymphangitis Lymphangiectasia Lymphedema Primary lymphedema Congenital lymphedema Lymphedema praecox Lymphedema tarda Lymphedema–distichiasis syndrome Milroy's disease Secondary lymphedema Bullous lymphedema Factitial lymphedema Postinflammatory lymphedema Postmastectomy lymphangiosarcoma Waldmann disease

Hypogammaglobulinemia	X-linked agammaglobulinemia Transient hypogammaglobulinemia of infancy
Dysgammaglobulinemia	IgA deficiency IgG deficiency IgM deficiency Hyper IgM syndrome (1 2 3 4 5) Wiskott–Aldrich syndrome Hyper-IgE syndrome
Other	Common variable immunodeficiency ICF syndrome