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Tenatoprazole

From Wikipedia, the free encyclopedia

Tenatoprazole
Clinical data
Routes of
administration		Oral
ATC code
  • none
Pharmacokinetic data
MetabolismHepatic (CYP2C19-mediated)
Elimination half-life4.8 to 7.7 hours
Identifiers
  • 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-imidazo[4,5-b]pyridine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.120.697 Edit this at Wikidata
Chemical and physical data
FormulaC16H18N4O3S
Molar mass346.41 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • Cc1c(OC)c(C)cnc1CS(=O)c2[nH]c3ccc(OC)nc3n2
  • InChI=1S/C16H18N4O3S/c1-9-7-17-12(10(2)14(9)23-4)8-24(21)16-18-11-5-6-13(22-3)19-15(11)20-16/h5-7H,8H2,1-4H3,(H,18,19,20) checkY
  • Key:ZBFDAUIVDSSISP-UHFFFAOYSA-N checkY
  (verify)

Tenatoprazole is a proton pump inhibitor drug candidate that was undergoing clinical testing as a potential treatment for reflux oesophagitis and peptic ulcer as far back as 2003.[1] The compound was invented by Mitsubishi Tanabe Pharma and was licensed to Negma Laboratories (part of Wockhardt as of 2007[2]).[3]: 22 

Mitsubishi reported that tenatoprazole was still in Phase I clinical trials in 2007[4]: 27  and again in 2012.[3]: 17 

Tenatoprazole has an imidazopyridine ring in place of the benzimidazole moiety found in other proton pump inhibitors, and has a half-life about seven times longer than other PPIs.[5]

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Transcription

See also

References

  1. ^ "Gastrointestinal Disease Update". Digestive Disease Week. DataMonitor. March 2003.
  2. ^ "Investors unwilling to forgive Wockhardt, promoter for failings". Economic Times. 3 March 2011.
  3. ^ a b "State of New Product Development" (PDF). Mitsubishi Tanabe Pharma. 8 May 2012.
  4. ^ "FY2007 Interim Financial Results". Mitsubishi Tanabe Pharma.
  5. ^ Li H, Meng L, Liu F, Wei JF, Wang YQ (January 2013). "H+/K+-ATPase inhibitors: a patent review". Expert Opinion on Therapeutic Patents. 23 (1): 99–111. doi:10.1517/13543776.2013.741121. PMID 23205582. S2CID 44647770.
This page was last edited on 5 April 2023, at 23:27
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