TUBGCP5

TUBGCP5

Identifiers

TUBGCP5, GCP5, tubulin gamma complex associated protein 5

External IDs

OMIM: 608147 MGI: 2178836 HomoloGene: 14172 GeneCards: TUBGCP5

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q11.2	Start	22,983,192 bp^[1]
Band	15q11.2	End	23,039,572 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B5	Start	55,443,902 bp^[2]
Band	7\|7 B5	End	55,481,425 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

Achilles tendon

corpus callosum

endometrium

body of pancreas

thymus

canal of the cervix

smooth muscle tissue

thyroid gland

adrenal gland

Top expressed in

spermatocyte

ascending aorta

aortic valve

superior cervical ganglion

facial motor nucleus

anterior horn of spinal cord

secondary oocyte

cerebellar cortex

superior frontal gyrus

olfactory epithelium

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	microtubule binding structural constituent of cytoskeleton microtubule minus-end binding gamma-tubulin binding
Cellular component	centrosome spindle pole equatorial microtubule organizing center microtubule organizing center spindle pole body microtubule cytoskeleton cytoplasm cytosol gamma-tubulin complex
Biological process	centrosome duplication microtubule nucleation by interphase microtubule organizing center mitotic spindle assembly cytoplasmic microtubule organization microtubule cytoskeleton organization microtubule nucleation meiosis mitotic cell cycle spindle assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


114791


233276

Ensembl


ENSG00000276856 ENSG00000275835 ENSG00000280807


ENSMUSG00000033790

UniProt


Q96RT8


Q8BKN5

RefSeq (mRNA)

NM_001102610 NM_052903 NM_001354372 NM_001354373 NM_001354374
NM_001354375 NM_001354376 NM_001354377 NM_001354378


NM_146190 NM_001360873 NM_001360874

RefSeq (protein)

NP_001096080 NP_443135 NP_001341301 NP_001341302 NP_001341303
NP_001341304 NP_001341305 NP_001341306 NP_001341307


NP_666302 NP_001347802 NP_001347803

Location (UCSC)

Chr 15: 22.98 – 23.04 Mb

Chr 7: 55.44 – 55.48 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Gamma-tubulin complex component 5 is a protein that in humans is encoded by the TUBGCP5 gene.^[5]^[6] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

References

^ ^a ^b ^c ENSG00000275835, ENSG00000280807 GRCh38: Ensembl release 89: ENSG00000276856, ENSG00000275835, ENSG00000280807 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033790 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (Nov 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex" (PDF). Mol Biol Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
^ "Entrez Gene: TUBGCP5 tubulin, gamma complex associated protein 5".

Bittel DC, Kibiryeva N, Butler MG (2006). "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader–Willi syndrome". Pediatrics. 118 (4): e1276–83. doi:10.1542/peds.2006-0424. PMC 5453799. PMID 16982806.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chai JH, Locke DP, Greally JM, et al. (2003). "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons". Am. J. Hum. Genet. 73 (4): 898–925. doi:10.1086/378816. PMC 1180611. PMID 14508708.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.

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This page was last edited on 4 March 2023, at 02:07

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See also

References

Further reading