TNNI3K

TNNI3K

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4YFI, 4YFF

Identifiers

Aliases

TNNI3K, CARK, CCDD, TNNI3 interacting kinase

External IDs

OMIM: 613932 MGI: 2443276 HomoloGene: 41084 GeneCards: TNNI3K

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p31.1	Start	74,235,387 bp^[1]
Band	1p31.1	End	74,544,428 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 H4	Start	154,491,928 bp^[2]
Band	3\|3 H4	End	154,761,044 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left ventricle

cerebellar hemisphere

Brodmann area 9

superior frontal gyrus

sural nerve

prefrontal cortex

cingulate gyrus

corpus callosum

Achilles tendon

nucleus accumbens

Top expressed in

myocardium of ventricle

atrium

atrioventricular valve

endocardial cushion

left ventricle

olfactory epithelium

semi-lunar valve

aortic valve

esophagus

aorta

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity protein kinase activity protein serine/threonine kinase activity nucleotide binding protein C-terminus binding protein binding troponin I binding ATP binding metal ion binding kinase activity signal transducer activity
Cellular component	cytoplasm nucleus
Biological process	protein phosphorylation regulation of cardiac muscle contraction regulation of cardiac conduction bundle of His cell to Purkinje myocyte communication phosphorylation regulation of heart rate intracellular signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51086


435766

Ensembl


ENSG00000116783


ENSMUSG00000040086

UniProt


Q59H18


Q5GIG6

RefSeq (mRNA)


NM_015978


NM_001012364 NM_177066

RefSeq (protein)


NP_001106279 NP_001186256 NP_057062


NP_796040

Location (UCSC)

Chr 1: 74.24 – 74.54 Mb

Chr 3: 154.49 – 154.76 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

TNNI3 interacting kinase is a protein that in humans is encoded by the TNNI3K gene.^[5]

Function

This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology.^[5]

Clinical significance

Mutations in TNNI3K are associated to cardiomyopathies.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116783 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040086 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TNNI3 interacting kinase".
^ Theis JL, Zimmermann MT, Larsen BT, Rybakova IN, Long PA, Evans JM, Middha S, de Andrade M, Moss RL, Wieben ED, Michels VV, Olson TM (Nov 2014). "TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy". Human Molecular Genetics. 23 (21): 5793–804. doi:10.1093/hmg/ddu297. PMC 4189907. PMID 24925317.

Yang SW, Hitz MP, Andelfinger G (Oct 2010). "Ventricular septal defect and restrictive cardiomyopathy in a paediatric TNNI3 mutation carrier". Cardiology in the Young. 20 (5): 574–6. doi:10.1017/S1047951110000715. PMID 20569525. S2CID 20594665.
Wang L, Wang H, Ye J, Xu RX, Song L, Shi N, Zhang YW, Chen X, Meng XM (Apr 2011). "Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy". Clinical and Experimental Pharmacology & Physiology. 38 (4): 278–84. doi:10.1111/j.1440-1681.2011.05499.x. PMID 21314842. S2CID 32451541.
Wei YJ, Cui CJ, Huang YX, Zhang XL, Zhang H, Hu SS (Jun 2009). "Upregulated expression of cardiac ankyrin repeat protein in human failing hearts due to arrhythmogenic right ventricular cardiomyopathy". European Journal of Heart Failure. 11 (6): 559–66. doi:10.1093/eurjhf/hfp049. PMID 19359327.
Chen X, Li X, Wang P, Liu Y, Zhang Z, Zhao G, Xu H, Zhu J, Qin X, Chen S, Hu L, Kong X (2010). "Novel association strategy with copy number variation for identifying new risk Loci of human diseases". PLOS ONE. 5 (8): e12185. Bibcode:2010PLoSO...512185C. doi:10.1371/journal.pone.0012185. PMC 2924882. PMID 20808825.
Tang H, Xiao K, Mao L, Rockman HA, Marchuk DA (Jan 2013). "Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction". Journal of Molecular and Cellular Cardiology. 54: 101–11. doi:10.1016/j.yjmcc.2012.10.004. PMC 3535516. PMID 23085512.
Lai ZF, Chen YZ, Feng LP, Meng XM, Ding JF, Wang LY, Ye J, Li P, Cheng XS, Kitamoto Y, Monzen K, Komuro I, Sakaguchi N, Kim-Mitsuyama S (Aug 2008). "Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury". American Journal of Physiology. Heart and Circulatory Physiology. 295 (2): H708–16. doi:10.1152/ajpheart.00252.2008. PMID 18552163. S2CID 40248367.
Feng Y, Cao HQ, Liu Z, Ding JF, Meng XM (Jun 2007). "Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K". General Physiology and Biophysics. 26 (2): 104–9. PMID 17660584.
Feng Y, Liu DQ, Wang Z, Liu Z, Cao HQ, Wang LY, Shi N, Meng XM (Nov 2007). "AOP-1 interacts with cardiac-specific protein kinase TNNI3K and down-regulates its kinase activity". Biochemistry. Biokhimiia. 72 (11): 1199–204. doi:10.1134/s0006297907110053. PMID 18205602. S2CID 32928443.
Cousminer DL, Berry DJ, Timpson NJ, Ang W, Thiering E, Byrne EM, et al. (Jul 2013). "Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity". Human Molecular Genetics. 22 (13): 2735–47. doi:10.1093/hmg/ddt104. PMC 3674797. PMID 23449627.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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This page was last edited on 11 October 2022, at 18:37

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Function

Clinical significance

References

Further reading