TLL1

TLL1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3EDI

Identifiers

Aliases

TLL1, ASD6, TLL, tolloid like 1

External IDs

OMIM: 606742 MGI: 106923 HomoloGene: 49202 GeneCards: TLL1

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q32.3	Start	165,873,237 bp^[1]
Band	4q32.3	End	166,104,457 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8 B3.1\|8 32.19 cM	Start	64,467,965 bp^[2]
Band	8 B3.1\|8 32.19 cM	End	64,659,305 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

cerebellar cortex

cerebellar hemisphere

Achilles tendon

gallbladder

smooth muscle tissue

subcutaneous adipose tissue

left uterine tube

skin of abdomen

canal of the cervix

Top expressed in

vein

interatrial septum

secondary oocyte

endocardium of ventricle

electrical conduction system of the heart

sinus venosus

cerebellar cortex

vena cava

granular layer

sclerotome

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium ion binding zinc ion binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metalloendopeptidase activity serine-type endopeptidase activity
Cellular component	extracellular region
Biological process	multicellular organism development skeletal system development cell differentiation extracellular matrix disassembly proteolysis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7092


21892

Ensembl


ENSG00000038295


ENSMUSG00000053626

UniProt


O43897


Q62381

RefSeq (mRNA)


NM_001204760 NM_012464


NM_009390

RefSeq (protein)


NP_001191689 NP_036596


NP_033416

Location (UCSC)

Chr 4: 165.87 – 166.1 Mb

Chr 8: 64.47 – 64.66 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.^[5]^[6]

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000038295 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053626 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet. 86 (1): 64–65. doi:10.1159/000015412. PMID 10516436. S2CID 42081614.
^ ^a ^b "Entrez Gene: TLL1 tolloid-like 1".

Takahara K, Brevard R, Hoffman GG, et al. (1997). "Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1". Genomics. 34 (2): 157–165. doi:10.1006/geno.1996.0260. PMID 8661043.
Scott IC, Blitz IL, Pappano WN, et al. (1999). "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis". Dev. Biol. 213 (2): 283–300. doi:10.1006/dbio.1999.9383. PMID 10479448.
Scott IC, Imamura Y, Pappano WN, et al. (2000). "Bone morphogenetic protein-1 processes probiglycan". J. Biol. Chem. 275 (39): 30504–30511. doi:10.1074/jbc.M004846200. PMID 10896944.
Uzel MI, Scott IC, Babakhanlou-Chase H, et al. (2001). "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures". J. Biol. Chem. 276 (25): 22537–22543. doi:10.1074/jbc.M102352200. PMID 11313359.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006). "Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains". J. Biol. Chem. 281 (16): 10786–10798. doi:10.1074/jbc.M511111200. PMID 16507574.

v t e Intercellular signaling peptides and proteins / ligands
Growth factors	Epidermal growth factor Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor beta superfamily Vascular endothelial growth factor
Ephrin	EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3
Other	Adipokine Agouti signaling protein Agouti-related protein Angiogenic protein CCN intercellular signaling protein Cysteine-rich protein 61 Connective tissue growth factor Nephroblastoma overexpressed protein Cytokine Endothelin EDN1 EDN2 EDN3 Hedgehog protein Interferon Kinin Parathyroid hormone-related protein Semaphorin Somatomedin Tolloid-like metalloproteinase Tumor necrosis factor Wnt protein
see also extracellular ligand disorders

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This page was last edited on 24 December 2022, at 17:35

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References

Further reading