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TINF2

From Wikipedia, the free encyclopedia

TINF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTINF2, DKCA3, TIN2, TERF1 interacting nuclear factor 2
External IDsOMIM: 604319 MGI: 107246 HomoloGene: 8264 GeneCards: TINF2
Orthologs
SpeciesHumanMouse
Entrez

26277

28113

Ensembl

ENSG00000092330
ENSG00000284915

ENSMUSG00000007589

UniProt

Q9BSI4

Q9QXG9
Q8K1K3

RefSeq (mRNA)

NM_001099274
NM_012461
NM_001363668

NM_145705

RefSeq (protein)

NP_001092744
NP_036593
NP_001350597

NP_663751

Location (UCSC)Chr 14: 24.24 – 24.24 MbChr 14: 55.91 – 55.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.[5][6] TINF2 is a component of the shelterin protein complex found at the end of telomeres.[7]

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Transcription

Interactions

TINF2 has been shown to interact with ACD,[8][9] POT1[8][9][10] and TERF1.[5][9][11]

References

  1. ^ a b c ENSG00000284915 GRCh38: Ensembl release 89: ENSG00000092330, ENSG00000284915 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007589 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kim SH, Kaminker P, Campisi J (Dec 1999). "TIN2, a new regulator of telomere length in human cells". Nature Genetics. 23 (4): 405–12. doi:10.1038/70508. PMC 4940194. PMID 10581025.
  6. ^ "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2".
  7. ^ Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008). "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". American Journal of Human Genetics. 82 (2): 501–9. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230.
  8. ^ a b Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development. 18 (14): 1649–54. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715.
  9. ^ a b c Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449. S2CID 11543383.
  10. ^ Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. Bibcode:2003Natur.423.1013L. doi:10.1038/nature01688. PMID 12768206. S2CID 4370276.
  11. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.

Further reading

External links

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This page was last edited on 4 January 2024, at 10:20
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