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| Formula | C21H19ClN4O2 |
| Molar mass | 394.86 g·mol−1 |
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SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain, which may be linked to its neuroprotective action.[1][2][3][4]
See also
References
- ^ Ferzaz B, Brault E, Bourliaud G, Robert JP, Poughon G, Claustre Y, et al. (June 2002). "SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair". The Journal of Pharmacology and Experimental Therapeutics. 301 (3): 1067–78. doi:10.1124/jpet.301.3.1067. PMID 12023539. S2CID 16732360.
- ^ Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, et al. (September 2003). "Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion". The Journal of Pharmacology and Experimental Therapeutics. 306 (3): 828–37. doi:10.1124/jpet.103.052068. PMID 12928523. S2CID 1101660.
- ^ Kunduzova OR, Escourrou G, De La Farge F, Salvayre R, Séguélas MH, Leducq N, et al. (August 2004). "Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion". Journal of the American Society of Nephrology. 15 (8): 2152–60. doi:10.1097/01.ASN.0000133563.41148.74. PMID 15284300.
- ^ Veenman L, Gavish M (June 2006). "The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development". Pharmacology & Therapeutics. 110 (3): 503–24. doi:10.1016/j.pharmthera.2005.09.007. PMID 16337685.
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This page was last edited on 25 January 2024, at 14:40