SRD5A3

SRD5A3

Identifiers

SRD5A3, CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1, steroid 5 alpha-reductase 3

External IDs

OMIM: 611715 MGI: 1930252 HomoloGene: 41385 GeneCards: SRD5A3

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q12	Start	55,346,213 bp^[1]
Band	4q12	End	55,373,100 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 C3.3	Start	76,288,118 bp^[2]
Band	5\|5 C3.3	End	76,303,351 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

palpebral conjunctiva

gallbladder

body of pancreas

islet of Langerhans

stromal cell of endometrium

minor salivary gland

left adrenal gland

right adrenal gland

skin of abdomen

prefrontal cortex

Top expressed in

secondary oocyte

internal carotid artery

yolk sac

external carotid artery

condyle

ascending aorta

proximal tubule

sciatic nerve

aortic valve

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors cholestenone 5-alpha-reductase activity oxidoreductase activity 3-oxo-5-alpha-steroid 4-dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor polyprenol reductase activity
Cellular component	cytoplasm integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum
Biological process	lipid metabolism polyprenol catabolic process androgen biosynthetic process protein glycosylation dolichol metabolic process dolichyl diphosphate biosynthetic process dolichol-linked oligosaccharide biosynthetic process dolichol biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79644


57357

Ensembl


ENSG00000128039


ENSMUSG00000029233

UniProt


Q9H8P0


Q9WUP4

RefSeq (mRNA)


NM_024592


NM_020611

RefSeq (protein)


NP_078868


NP_065636

Location (UCSC)

Chr 4: 55.35 – 55.37 Mb

Chr 5: 76.29 – 76.3 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.^[5]^[6] It is one of three forms of 5α-reductase.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128039 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029233 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: steroid 5 alpha-reductase 3".
^ Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H (January 2008). "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer". Cancer Sci. 99 (1): 81–6. doi:10.1111/j.1349-7006.2007.00656.x. PMID 17986282. S2CID 51733620.

Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocr. Rev. 25 (6): 947–70. doi:10.1210/er.2003-0030. PMID 15583024.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cantagrel V, Lefeber DJ, Ng BG, et al. (2010). "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell. 142 (2): 203–17. doi:10.1016/j.cell.2010.06.001. PMC 2940322. PMID 20637498.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

v t e Oxidoreductases: CH–CH oxidoreductases (EC 1.3)
1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase
1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase
1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD
1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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This page was last edited on 28 October 2022, at 03:49

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See also

References

Further reading