Rnd1

RND1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CLS, 2REX, 3Q3J

Identifiers

Aliases

RND1, ARHS, RHO6, RHOS, Rnd1, Rho family GTPase 1

External IDs

OMIM: 609038 MGI: 2444878 HomoloGene: 8706 GeneCards: RND1

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.12	Start	48,857,145 bp^[1]
Band	12q13.12	End	48,865,870 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 F1	Start	98,561,302 bp^[2]
Band	15\|15 F1	End	98,575,342 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

vena cava

right lobe of liver

frontal pole

prefrontal cortex

middle temporal gyrus

dorsolateral prefrontal cortex

Brodmann area 9

cingulate gyrus

secondary oocyte

Brodmann area 10

Top expressed in

morula

cerebellar cortex

superior frontal gyrus

dorsomedial hypothalamic nucleus

blastocyst

anterior horn of spinal cord

dorsal tegmental nucleus

facial motor nucleus

lateral hypothalamus

ventral tegmental area

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding GTP binding signaling receptor binding protein binding GTPase activity protein kinase binding
Cellular component	cytoplasm adherens junction cytosol cytoskeleton membrane plasma membrane actin cytoskeleton intracellular membrane-bounded organelle intracellular anatomical structure cell cortex cell division site
Biological process	neuron remodeling small GTPase mediated signal transduction negative regulation of cell adhesion actin filament organization Rho protein signal transduction regulation of cell shape regulation of cell migration establishment or maintenance of actin cytoskeleton polarity regulation of actin cytoskeleton organization actin filament bundle assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


27289


223881

Ensembl


ENSG00000172602


ENSMUSG00000054855

UniProt


Q92730


Q8BLR7

RefSeq (mRNA)


NM_014470


NM_172612

RefSeq (protein)


NP_055285


NP_766200

Location (UCSC)

Chr 12: 48.86 – 48.87 Mb

Chr 15: 98.56 – 98.58 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.^[5] It is encoded by the gene RND1.^[6]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]^[6]

Interactions

Rnd1 has been shown to interact with GRB7,^[7] PLXNB1,^[8] PDE6D,^[9]^[10] ARHGAP5^[11] and UBXD5.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172602 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054855 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ridley AJ (Oct 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
^ ^a ^b "Entrez Gene: RND1 Rho family GTPase 1".
^ Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Letters. 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. PMID 10664463. S2CID 4901644.
^ Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". The Journal of Biological Chemistry. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
^ Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
^ Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
^ Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Current Biology. 13 (13): 1106–15. Bibcode:2003CBio...13.1106W. doi:10.1016/S0960-9822(03)00418-4. PMC 6918695. PMID 12842009.
^ Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular Biology. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC 133765. PMID 11940653.

Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P (Apr 1998). "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion". The Journal of Cell Biology. 141 (1): 187–97. doi:10.1083/jcb.141.1.187. PMC 2132722. PMID 9531558.
Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Letters. 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. PMID 10664463. S2CID 4901644.
Aoki J, Katoh H, Mori K, Negishi M (Nov 2000). "Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells". Biochemical and Biophysical Research Communications. 278 (3): 604–8. doi:10.1006/bbrc.2000.3842. PMID 11095956.
Rohm B, Rahim B, Kleiber B, Hovatta I, Püschel AW (Dec 2000). "The semaphorin 3A receptor may directly regulate the activity of small GTPases". FEBS Letters. 486 (1): 68–72. doi:10.1016/S0014-5793(00)02240-7. PMID 11108845. S2CID 7914214.
Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular Biology. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC 133765. PMID 11940653.
Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". The Journal of Biological Chemistry. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
Oinuma I, Ishikawa Y, Katoh H, Negishi M (Aug 2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science. 305 (5685): 862–5. Bibcode:2004Sci...305..862O. doi:10.1126/science.1097545. PMID 15297673. S2CID 39544623.
Harada A, Katoh H, Negishi M (May 2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells". The Journal of Biological Chemistry. 280 (18): 18418–24. doi:10.1074/jbc.M411356200. PMID 15738000.
Kim YS, Hori M, Yasuda K, Ozaki H (Dec 2005). "Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria". Comparative Biochemistry and Physiology A. 142 (4): 410–5. doi:10.1016/j.cbpa.2005.08.028. PMID 16311049.

v t e PDB gallery
2cls: THE CRYSTAL STRUCTURE OF THE HUMAN RND1 GTPASE IN THE ACTIVE GTP BOUND STATE

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B
Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2
Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4
H+/K+ (3.6.3.10)	ATP4A
Other P-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5: GTPase

3.6.5.1: Heterotrimeric G protein	G_αs G_olf G_αi GNAI1 GNAI2 GNAI3 Transducin GNAT1 GNAT2 Gustducin GNAT3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13
3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other: Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK
3.6.5.3: Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic
3.6.5.5-6: Polymerization motors	dynamin superfamily Dynamin Guanylate-binding protein Mitofusin-1 MX1 and MX2 OPA1 Tubulin

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This page was last edited on 11 April 2024, at 17:20

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Interactions

References

Further reading