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Ravuconazole

From Wikipedia, the free encyclopedia

Ravuconazole
Clinical data
ATC code
  • None
Identifiers
  • 4-[2-[(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H17F2N5OS
Molar mass437.47 g·mol−1
3D model (JSmol)
  • C[C@@H](c1nc(-c2ccc(C#N)cc2)cs1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
  • InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1 ☒N
  • Key:OPAHEYNNJWPQPX-RCDICMHDSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007.[1] The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life.[2] However, ravuconazole has limited activity against species of Fusarium, Scedosporium, and Zygomycetes.[3][4]

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Transcription

See also

References

  1. ^ "Ravuconazole". AdisInsight. Springer Nature Switzerland AG. Retrieved 12 November 2017.
  2. ^ Pasqualotto AC, Denning DW. "Ravuconazole". The Aspergillus Website. Retrieved 18 February 2010.
  3. ^ Pasqualotto AC, Thiele KO, Goldani LZ (February 2010). "Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole". Current Opinion in Investigational Drugs. 11 (2): 165–174. PMID 20112166.
  4. ^ Pfaller MA, Messer SA, Hollis RJ, Jones RN (April 2002). "Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program, 2000". Antimicrobial Agents and Chemotherapy. 46 (4): 1032–1037. doi:10.1128/AAC.46.4.1032-1037.2002. PMC 127116. PMID 11897586.

External links

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This page was last edited on 17 October 2023, at 05:57
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