RTN2

RTN2

Identifiers

RTN2, NSP2, NSPL1, NSPLI, SPG12, reticulon 2

External IDs

OMIM: 603183 MGI: 107612 HomoloGene: 32180 GeneCards: RTN2

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.32	Start	45,485,294 bp^[1]
Band	19q13.32	End	45,497,055 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 A3\|7 9.54 cM	Start	19,016,549 bp^[2]
Band	7 A3\|7 9.54 cM	End	19,030,085 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastrocnemius muscle

vastus lateralis muscle

thoracic diaphragm

triceps brachii muscle

biceps brachii

body of tongue

deltoid muscle

tibialis anterior muscle

Brodmann area 10

spinal ganglia

Top expressed in

triceps brachii muscle

temporal muscle

sternocleidomastoid muscle

ankle

digastric muscle

extensor digitorum longus muscle

vastus lateralis muscle

tibialis anterior muscle

soleus muscle

plantaris muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	integral component of membrane T-tubule integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane terminal cisterna
Biological process	intracellular protein transmembrane transport regulation of glucose import
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6253


20167

Ensembl


ENSG00000125744


ENSMUSG00000030401

UniProt


O75298 Q96CG9


O70622

RefSeq (mRNA)


NM_206902 NM_005619 NM_206900 NM_206901


NM_001025364 NM_013648

RefSeq (protein)


NP_005610 NP_996783 NP_996784


NP_001020535 NP_038676

Location (UCSC)

Chr 19: 45.49 – 45.5 Mb

Chr 7: 19.02 – 19.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.^[5]^[6]^[7]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125744 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030401 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK (Dec 1996). "Detailed comparative map of human chromosome 19q and related regions of the mouse genome". Genomics. 35 (3): 499–508. doi:10.1006/geno.1996.0390. PMID 8812484.
^ Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML (May 1998). "Molecular cloning of a novel mouse gene with predominant muscle and neural expression". Mamm Genome. 9 (4): 274–82. doi:10.1007/s003359900748. PMID 9530622. S2CID 7091637.
^ ^a ^b "Entrez Gene: RTN2 reticulon 2".

Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID 15286784. S2CID 23570406.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family". FASEB J. 17 (10): 1238–47. doi:10.1096/fj.02-1166hyp. PMID 12832288. S2CID 27903.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Geisler JG, Palmer RJ, Stubbs LJ, Mucenski ML (2000). "Nspl1, a new Z-band-associated protein". J. Muscle Res. Cell. Motil. 20 (7): 661–8. doi:10.1023/A:1005533013926. PMID 10672514. S2CID 26327921.
Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ (1998). "cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons". Genomics. 51 (1): 98–106. doi:10.1006/geno.1997.5175. PMID 9693037.

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This page was last edited on 28 March 2024, at 02:24

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References

Further reading