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Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene.
[5]RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C), and degrades the RNA of RNA:DNA hybrids.
This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene.
^Crow YJ, Leitch A, Hayward BE, Garner A, Parmar R, Griffith E, et al. (Aug 2006). "Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection". Nature Genetics. 38 (8): 910–6. doi:10.1038/ng1842. PMID16845400. S2CID8076225.
Further reading
Behlke MA, Bogan JS, Beer-Romero P, Page DC (1993). "Evidence that the SRY protein is encoded by a single exon on the human Y chromosome". Genomics. 17 (3): 736–9. doi:10.1006/geno.1993.1395. PMID8244390.
This page was last edited on 4 March 2023, at 00:47