RAP1GAP2

RAP1GAP2

Identifiers

RAP1GAP2, GARNL4, RAP1GA3, RAP1 GTPase activating protein 2

External IDs

MGI: 3028623 HomoloGene: 56695 GeneCards: RAP1GAP2

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17p13.3	Start	2,755,705 bp^[1]
Band	17p13.3	End	3,037,741 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B5	Start	74,274,182 bp^[2]
Band	11\|11 B5	End	74,501,741 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

middle temporal gyrus

endothelial cell

superior frontal gyrus

islet of Langerhans

postcentral gyrus

cerebellar vermis

entorhinal cortex

blood

pancreatic ductal cell

Top expressed in

islet of Langerhans

primary motor cortex

medial vestibular nucleus

submandibular gland

prefrontal cortex

cingulate gyrus

pontine nuclei

epithelium of stomach

interventricular septum

visual cortex

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding GTPase activator activity
Cellular component	perinuclear region of cytoplasm neuron projection centrosome plasma membrane nuclear membrane cytoplasm cytosol
Biological process	regulation of cell size positive regulation of GTPase activity negative regulation of neuron projection development regulation of small GTPase mediated signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23108


380711

Ensembl


ENSG00000132359


ENSMUSG00000038807

UniProt


Q684P5


Q5SVL6

RefSeq (mRNA)


NM_001100398 NM_015085 NM_001330058


NM_001015046 NM_001364131 NM_001364132

RefSeq (protein)


NP_001093868 NP_001316987 NP_055900


NP_001015046 NP_001351060 NP_001351061 NP_001388587

Location (UCSC)

Chr 17: 2.76 – 3.04 Mb

Chr 11: 74.27 – 74.5 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.^[5]

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132359 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038807 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAP1 GTPase activating protein 2".

Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP (August 2009). "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood. 114 (7): 1396–404. doi:10.1182/blood-2008-05-155234. hdl:10197/5848. PMID 19528539. S2CID 24339637.
Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH (June 2011). "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders. 11: 29. doi:10.1186/1471-2261-11-29. PMC 3141757. PMID 21658281.
Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M (October 2004). "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research. 300 (1): 84–93. doi:10.1016/j.yexcr.2004.07.011. PMID 15383317.
Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F (October 2011). "p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1". Cardiovascular Research. 92 (1): 149–58. doi:10.1093/cvr/cvr154. PMID 21632882.
Schultess J, Danielewski O, Smolenski AP (April 2005). "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood. 105 (8): 3185–92. doi:10.1182/blood-2004-09-3605. hdl:10197/5867. PMID 15632203.
Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP (January 2008). "Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets" (PDF). The Journal of Biological Chemistry. 283 (4): 2297–306. doi:10.1074/jbc.M706825200. PMID 18039662. S2CID 20190382.

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This page was last edited on 5 January 2024, at 18:05

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References

Further reading