PCDHA9

PCDHA9
Identifiers
Aliases	PCDHA9, PCDH-ALPHA9, protocadherin alpha 9
External IDs	OMIM: 606315; MGI: 2681879; HomoloGene: 129614; GeneCards: PCDHA9; OMA:PCDHA9 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 140,847,772 bp[1] End 141,012,347 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B2- B3 Start 37,125,424 bp[2] End 37,320,710 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve sperm Brodmann area 46 postcentral gyrus cerebellar vermis superior frontal gyrus lower lobe of lung ganglionic eminence entorhinal cortex pons Top expressed in neural tube olfactory bulb cerebellum mesencephalon hypothalamus cerebellar cortex superior frontal gyrus hippocampus proper islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9752 353235 Ensembl ENSG00000204961 ENSMUSG00000103800 UniProt Q9Y5H5 Q91Y12 RefSeq (mRNA) NM_031857 NM_014005 NM_201243 RefSeq (protein) NP_054724 NP_114063 NP_957695 Location (UCSC) Chr 5: 140.85 – 141.01 Mb Chr 18: 37.13 – 37.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene.^[5][6]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome 5 that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.^[6]

References

Further reading

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This page was last edited on 28 January 2023, at 22:11