Neuropilin 2

NRP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2QQJ, 2QQK, 2QQL, 2QQO, 4QDQ, 4QDR, 4QDS, 5DN2

Identifiers

Aliases

NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2

External IDs

OMIM: 602070 MGI: 1100492 HomoloGene: 2875 GeneCards: NRP2

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q33.3	Start	205,681,990 bp^[1]
Band	2q33.3	End	205,798,133 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 C2	Start	62,742,444 bp^[2]
Band	1\|1 C2	End	62,857,854 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

gastric mucosa

Achilles tendon

smooth muscle tissue

gallbladder

left uterine tube

left adrenal gland

right adrenal gland

myometrium

tibia

Top expressed in

calvaria

body of femur

habenula

dermis

olfactory tubercle

hair follicle

internal carotid artery

motor neuron

left lung lobe

external carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	vascular endothelial growth factor-activated receptor activity heparin binding semaphorin receptor activity growth factor binding metal ion binding cytokine binding protein binding identical protein binding signaling receptor activity
Cellular component	integral component of membrane membrane plasma membrane semaphorin receptor complex extracellular region axon glutamatergic synapse integral component of postsynaptic membrane
Biological process	sympathetic ganglion development cell differentiation semaphorin-plexin signaling pathway involved in neuron projection guidance positive regulation of endothelial cell proliferation vascular endothelial growth factor signaling pathway nervous system development axon guidance positive regulation of endothelial cell migration multicellular organism development sympathetic neuron projection guidance vascular endothelial growth factor receptor signaling pathway cell adhesion angiogenesis nerve development sympathetic neuron projection extension axon extension involved in axon guidance outflow tract septum morphogenesis neural crest cell migration neuron migration heart development facial nerve structural organization vestibulocochlear nerve structural organization gonadotrophin-releasing hormone neuronal migration to the hypothalamus ventral trunk neural crest cell migration negative chemotaxis trigeminal ganglion development sensory neuron axon guidance neural crest cell migration involved in autonomic nervous system development facioacoustic ganglion development dorsal root ganglion morphogenesis cellular response to leukemia inhibitory factor regulation of postsynapse organization viral process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8828


18187

Ensembl


ENSG00000118257


ENSMUSG00000025969

UniProt


O60462


O35375

RefSeq (mRNA)

NM_003872 NM_018534 NM_201264 NM_201266 NM_201267
NM_201279

NM_001077403 NM_001077404 NM_001077405 NM_001077406 NM_001077407
NM_010939

RefSeq (protein)

NP_003863 NP_061004 NP_957716 NP_957718 NP_957719
NP_958436

NP_001070871 NP_001070872 NP_001070873 NP_001070874 NP_001070875
NP_035069

Location (UCSC)

Chr 2: 205.68 – 205.8 Mb

Chr 1: 62.74 – 62.86 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.^[5]^[6]

This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease.^[7]^[8]^[9]^[10] Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118257 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025969 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (March 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell. 92 (6): 735–45. doi:10.1016/S0092-8674(00)81402-6. PMID 9529250. S2CID 547080.
^ Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348. S2CID 17985062.
^ Harman JL, Sayers J, Chapman C, Pellet-Many C (2020-07-21). "Emerging Roles for Neuropilin-2 in Cardiovascular Disease". International Journal of Molecular Sciences. 21 (14): 5154. doi:10.3390/ijms21145154. PMC 7404143. PMID 32708258.
^ Kofler N, Simons M (May 2016). "The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature". Current Opinion in Hematology. 23 (3): 260–7. doi:10.1097/MOH.0000000000000233. PMC 4957701. PMID 26849476.
^ Peng K, Bai Y, Zhu Q, Hu B, Xu Y (February 2019). "Targeting VEGF-neuropilin interactions: a promising antitumor strategy". Drug Discovery Today. 24 (2): 656–664. doi:10.1016/j.drudis.2018.10.004. PMID 30315890. S2CID 52979538.
^ Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H (November 1997). "Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice". Neuron. 19 (5): 995–1005. doi:10.1016/s0896-6273(00)80392-x. PMID 9390514. S2CID 17769318.
^ "Entrez Gene: NRP2 neuropilin 2".

Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (January 1999). "Vascular endothelial growth factor (VEGF) and its receptors". FASEB Journal. 13 (1): 9–22. doi:10.1096/fasebj.13.1.9. PMID 9872925. S2CID 1151216.
Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD (August 1997). "Neuropilin is a semaphorin III receptor". Cell. 90 (4): 753–62. doi:10.1016/S0092-8674(00)80535-8. PMID 9288754. S2CID 17268123.
Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (November 1998). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi:10.1016/S0896-6273(00)80625-X. PMID 9856463. S2CID 18445456.
Chen H, He Z, Bagri A, Tessier-Lavigne M (December 1998). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron. 21 (6): 1283–90. doi:10.1016/S0896-6273(00)80648-0. PMID 9883722.
Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (October 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nature Neuroscience. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546. S2CID 38320889.
Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (May 1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics. 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.
Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, et al. (October 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (June 2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". The Journal of Biological Chemistry. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.
Handa A, Tokunaga T, Tsuchida T, Lee YH, Kijima H, Yamazaki H, et al. (August 2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma". International Journal of Oncology. 17 (2): 291–5. doi:10.3892/ijo.17.2.291. PMID 10891538.
Rossignol M, Gagnon ML, Klagsbrun M (December 2000). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics. 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.
Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (June 2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes". The Journal of Biological Chemistry. 276 (22): 18688–94. doi:10.1074/jbc.M006909200. PMID 11278319.
Cohen T, Gluzman-Poltorak Z, Brodzky A, Meytal V, Sabo E, Misselevich I, et al. (June 2001). "Neuroendocrine cells along the digestive tract express neuropilin-2". Biochemical and Biophysical Research Communications. 284 (2): 395–403. doi:10.1006/bbrc.2001.4958. PMID 11394892.
Herzog Y, Kalcheim C, Kahane N, Reshef R, Neufeld G (November 2001). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins". Mechanisms of Development. 109 (1): 115–9. doi:10.1016/S0925-4773(01)00518-4. PMID 11677062. S2CID 18341197.
Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A, Honda Y (January 2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 383–8. Bibcode:2002PNAS...99..383O. doi:10.1073/pnas.012074399. PMC 117569. PMID 11756651.
Fakhari M, Pullirsch D, Abraham D, Paya K, Hofbauer R, Holzfeind P, et al. (January 2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer. 94 (1): 258–63. doi:10.1002/cncr.10177. PMID 11815985. S2CID 45773136.
Cohen T, Herzog Y, Brodzky A, Greenson JK, Eldar S, Gluzman-Poltorak Z, et al. (September 2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours". The Journal of Pathology. 198 (1): 77–82. doi:10.1002/path.1179. PMID 12210066. S2CID 24579823.
Kawakami T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Abe Y, et al. (November 2002). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma". Cancer. 95 (10): 2196–201. doi:10.1002/cncr.10936. PMID 12412174. S2CID 28744286.

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This page was last edited on 27 March 2024, at 21:53

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References

Further reading