NRD1

NRDC

Identifiers

NRDC, hNRD1, hNRD2, NRD1, nardilysin convertase, nardilysin

External IDs

OMIM: 602651; MGI: 1201386; HomoloGene: 68260; GeneCards: NRDC; OMA:NRDC - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p32.3	Start	51,789,191 bp^[1]
Band	1p32.3	End	51,878,805 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 C7	Start	108,857,852 bp^[2]
Band	4\|4 C7	End	108,918,974 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

triceps brachii muscle

gastrocnemius muscle

anterior pituitary

sperm

thoracic diaphragm

vastus lateralis muscle

tibial nerve

skin of abdomen

monocyte

right lobe of liver

Top expressed in

seminiferous tubule

spermatid

plantaris muscle

extensor digitorum longus muscle

lens

esophagus

skin of back

soleus muscle

superior frontal gyrus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	peptidase activity protein binding catalytic activity metallopeptidase activity hydrolase activity metal ion binding epidermal growth factor binding metalloendopeptidase activity
Cellular component	cell surface cytosol mitochondrion
Biological process	positive regulation of membrane protein ectodomain proteolysis cell population proliferation neuromuscular junction development cell migration regulation of endopeptidase activity proteolysis negative regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4898


230598

Ensembl


ENSG00000078618


ENSMUSG00000053510

UniProt


O43847


Q8BHG1

RefSeq (mRNA)


NM_001101662 NM_001242361 NM_002525


NM_146150 NM_001346554 NM_001347169

RefSeq (protein)


NP_001095132 NP_001229290 NP_002516


NP_001333483 NP_001334098 NP_666262

Location (UCSC)

Chr 1: 51.79 – 51.88 Mb

Chr 4: 108.86 – 108.92 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Nardilysin is a protein that in humans is encoded by the NRD1 gene.^[5]^[6]^[7]

Interactions

NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053510 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J. 327 (3): 773–9. doi:10.1042/bj3270773. PMC 1218856. PMID 9581555.
^ Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics. 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID 9479496.
^ "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)".
^ Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13). England: 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMC 125525. PMID 11432822.

Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu". Essays Biochem. 38: 79–94. doi:10.1042/bse0380079. PMID 12463163.
Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation". Protein Pept. Lett. 11 (5): 501–8. doi:10.2174/0929866043406508. PMID 15544571.
Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines". Biochem. J. 351 (3): 755–64. doi:10.1042/0264-6021:3510755. PMC 1221416. PMID 11042131.
Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. PMC 125525. PMID 11432822.
Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain". Biochemistry. 40 (31): 9447–52. doi:10.1021/bi010538x. PMID 11478915.
Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)". Biochem. J. 367 (Pt 1): 229–38. doi:10.1042/BJ20020822. PMC 1222870. PMID 12095415.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites". Biochemistry. 42 (7): 2239–44. doi:10.1021/bi027178d. PMID 12590613.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme". J. Biol. Chem. 281 (41): 31164–72. doi:10.1074/jbc.M601316200. PMID 16923819.
Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons". Neuroscience. 146 (4): 1513–23. doi:10.1016/j.neuroscience.2007.02.057. PMID 17442499. S2CID 8060302.

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This page was last edited on 8 April 2022, at 19:46

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Interactions

References

Further reading