mir-145

MIR145

Identifiers

MIR145, microRNA 145, MIRN145, miR-145, miRNA145, MIRN145 microRNA, human

External IDs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q32	Start	149,430,646 bp^[1]
Band	5q32	End	149,430,733 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right coronary artery

gastric mucosa

smooth muscle tissue

left uterine tube

myometrium

left coronary artery

prostate

fundus

thoracic aorta

ascending aorta

n/a

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


406937


n/a

Ensembl


ENSG00000276365


n/a

UniProt


n a


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 5: 149.43 – 149.43 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

mir-145
Conserved secondary structure of mir-145
Identifiers
Symbol	mir-145
Rfam	RF00675
miRBase family	MIPF0000079
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.^[3]

YouTube Encyclopedic

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Transcription

Targets

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin in breast cancer and endometriosis cells, resulting in a reduction of cell motility.^[4]^[5] Larsson et al.^[6] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.^[7]

Role in cancer

miR-145 is hypothesised to be a tumor suppressor.^[8] miR-145 has been shown to be down-regulated in breast cancer.^[5] miR-145 is also involved in colon cancer ^[7]^[9]^[10] and acute myeloid leukemia.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000276365 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MicroRNA 145". Retrieved 2015-01-26.
^ Adammek M (2013). "MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors". Fertility and Sterility. 99 (5): 1346–1355.e5. doi:10.1016/j.fertnstert.2012.11.055. PMID 23312222.
^ ^a ^b Götte M, Mohr C, Koo CY, et al. (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–80. doi:10.1038/onc.2010.386. PMID 20818426. S2CID 11455884.
^ Larsson E, Fredlund Fuchs P, Heldin J, et al. (2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine. 1 (11): 108. doi:10.1186/gm108. PMC 2808743. PMID 19917099.
^ ^a ^b Zhang J, Guo H, Zhang H, et al. (Jan 2011). "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene". Cancer. 117 (1): 86–95. doi:10.1002/cncr.25522. PMC 2995010. PMID 20737575.
^ Sachdeva M, Zhu S, Wu F, et al. (Mar 2009). "p53 represses c-Myc through induction of the tumor suppressor miR-145". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3207–12. Bibcode:2009PNAS..106.3207S. doi:10.1073/pnas.0808042106. PMC 2651330. PMID 19202062.
^ Slaby O, Svoboda M, Fabian P, et al. (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology. 72 (5–6): 397–402. doi:10.1159/000113489. PMID 18196926. S2CID 207615720.
^ Mazza T, Mazzoccoli G, Fusilli C, et al. (2016-05-19). "Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer". Nucleic Acids Research. 44 (9): 4025–4036. doi:10.1093/nar/gkw245. ISSN 1362-4962. PMC 4872111. PMID 27067546.
^ Starczynowski DT, Morin R, McPherson A, et al. (Jan 2011). "Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations". Blood. 117 (2): 595–607. doi:10.1182/blood-2010-03-277012. PMID 20962326.

Zhang J, Guo H, Qian G, et al. (2010). "MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network". Molecular Cancer. 9: 211. doi:10.1186/1476-4598-9-211. PMC 2924312. PMID 20687965.
Zaman MS, Chen Y, Deng G, et al. (Jul 2010). "The functional significance of microRNA-145 in prostate cancer". British Journal of Cancer. 103 (2): 256–64. doi:10.1038/sj.bjc.6605742. PMC 2906737. PMID 20588276.
Sachdeva M, Mo YY (2010). "miR-145-mediated suppression of cell growth, invasion and metastasis". American Journal of Translational Research. 2 (2): 170–80. PMC 2855636. PMID 20407606.
Kano M, Seki N, Kikkawa N, et al. (Dec 2010). "miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma". International Journal of Cancer. 127 (12): 2804–14. doi:10.1002/ijc.25284. PMID 21351259. S2CID 25480039.
Chiyomaru T, Enokida H, Tatarano S, et al. (Mar 2010). "miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer". British Journal of Cancer. 102 (5): 883–91. doi:10.1038/sj.bjc.6605570. PMC 2833258. PMID 20160723.
Gregersen LH, Jacobsen AB, Frankel LB, et al. (2010). Kudla G (ed.). "MicroRNA-145 targets YES and STAT1 in colon cancer cells". PLOS ONE. 5 (1): e8836. Bibcode:2010PLoSO...5.8836G. doi:10.1371/journal.pone.0008836. PMC 2809101. PMID 20098684.
Sachdeva M, Mo YY (Jan 2010). "MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1". Cancer Research. 70 (1): 378–87. doi:10.1158/0008-5472.CAN-09-2021. PMC 2805032. PMID 19996288.
Larsson E, Fredlund Fuchs P, Heldin J, et al. (2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine. 1 (11): 108. doi:10.1186/gm108. PMC 2808743. PMID 19917099.
Ostenfeld MS, Bramsen JB, Lamy P, et al. (Feb 2010). "miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors". Oncogene. 29 (7): 1073–84. doi:10.1038/onc.2009.395. PMID 19915607. S2CID 25309570.
Starczynowski DT, Kuchenbauer F, Argiropoulos B, et al. (Jan 2010). "Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype". Nature Medicine. 16 (1): 49–58. doi:10.1038/nm.2054. PMID 19898489. S2CID 7987486.
Arndt GM, Dossey L, Cullen LM, et al. (2009). "Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer". BMC Cancer. 9: 374. doi:10.1186/1471-2407-9-374. PMC 2770572. PMID 19843336.
Zhang C (Nov 2009). "MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease". Cell Cycle. 8 (21): 3469–73. doi:10.4161/cc.8.21.9837. PMC 3593963. PMID 19829088.
Zeng L, Carter AD, Childs SJ (Oct 2009). "miR-145 directs intestinal maturation in zebrafish". Proceedings of the National Academy of Sciences of the United States of America. 106 (42): 17793–8. Bibcode:2009PNAS..10617793Z. doi:10.1073/pnas.0903693106. PMC 2764920. PMID 19805048.
Spizzo R, Nicoloso MS, Lupini L, et al. (Feb 2010). "miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells". Cell Death and Differentiation. 17 (2): 246–54. doi:10.1038/cdd.2009.117. PMC 3648637. PMID 19730444.
Xin M, Small EM, Sutherland LB, et al. (Sep 2009). "MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury". Genes & Development. 23 (18): 2166–78. doi:10.1101/gad.1842409. PMC 2751981. PMID 19720868.
Cordes KR, Sheehy NT, White MP, et al. (Aug 2009). "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity". Nature. 460 (7256): 705–10. Bibcode:2009Natur.460..705C. doi:10.1038/nature08195. PMC 2769203. PMID 19578358.
Cheng Y, Liu X, Yang J, et al. (Jul 2009). "MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation". Circulation Research. 105 (2): 158–66. doi:10.1161/CIRCRESAHA.109.197517. PMC 2728297. PMID 19542014.
Cho WC, Chow AS, Au JS (Aug 2009). "Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation". European Journal of Cancer. 45 (12): 2197–206. doi:10.1016/j.ejca.2009.04.039. PMID 19493678.
Chivukula RR, Mendell JT (May 2009). "Abate and switch: miR-145 in stem cell differentiation". Cell. 137 (4): 606–8. doi:10.1016/j.cell.2009.04.059. PMID 19450510.
Xu N, Papagiannakopoulos T, Pan G, et al. (May 2009). "MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells". Cell. 137 (4): 647–58. doi:10.1016/j.cell.2009.02.038. PMID 19409607. S2CID 18601406.
La Rocca G, Badin M, Shi B, et al. (Aug 2009). "Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway". Journal of Cellular Physiology. 220 (2): 485–91. doi:10.1002/jcp.21796. PMID 19391107. S2CID 44343336.
Wang S, Bian C, Yang Z, et al. (May 2009). "miR-145 inhibits breast cancer cell growth through RTKN". International Journal of Oncology. 34 (5): 1461–6. doi:10.3892/ijo_00000275. PMID 19360360.
Zheng L, Pu J, Qi T, et al. (Feb 2013). "miRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells". Molecular Cancer Research. 11 (2): 182–93. doi:10.1158/1541-7786.MCR-12-0534. PMID 23233482.

External links

Page for mir-145 microRNA precursor family at Rfam

v t e miRNA precursor families
1-100	1 2 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 26 29 30 31 33 34 46/47/281 48 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 155 156 160 166 172 181 184 190 191 192/215 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401+	433 451 455 489 535 542 589 598 612 612 612 625 632 636 661 711 720 764 765 872 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

This page was last edited on 11 April 2024, at 11:01

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