To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
Languages
Recent
Show all languages
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
.
Leo
Newton
Brights
Milds

Maternal hypothyroidism

From Wikipedia, the free encyclopedia

Maternal hypothyroidism is hypothyroidism in pregnant mothers.[1]

Overview

Even with appropriate treatment, it may pose risks not only to the mother, but also to the fetus. Thyroid hormones, T4 and TSH, diffuse across the placenta traveling from the mother to fetus for 10–12 weeks before the fetus’s own thyroid gland can begin synthesizing its own thyroid hormones.[2] The mother continues to supply some T4 to the fetus even after he/she is able to synthesize his/her own. Infants with sporadic congenital hypothyroidism show T4 concentrations in the umbilical cord suggesting the mother is still providing 25-50 percent of T4. If these infants are not screened soon after birth for their hypothyroidism and treated, the infants can become permanently intellectually disabled, since they can’t meet their bodies demand for T4.[3]

One study showed infants born to treated hypothyroid mothers had abnormal thyroid function compared to matched controls.[2] Therefore, it is advised to monitor T4 levels throughout the pregnancy in case treatment dosages should be increased to accommodate both the mother’s and fetus’s thyroid hormone requirements. If the supply of T4 is insufficient the mother may be at risk for preeclampsia and preterm delivery.[3]

The infants may also be at risk for suppressed psychomotor development and slightly lower IQ.[3] In a study of induced hypothyroidism in pregnant rats they were able to find lower levels of growth hormone in both the blood and pituitary gland of the offspring.[4] This study also looked at neural development in rats and found that maternal hypothyroidism in rat mothers is related to deterioration, damage, disorganization and malformation of neurons and dendrites in the pups, which may result from an impaired antioxidant defense system and high levels of oxidative stress.[4]

References

  1. ^ "Hypothyroidism in Pregnancy". American Thyroid Association. Retrieved 2020-10-29.
  2. ^ a b Blazer S.; Moreh-Waterman Y.; Miller-Lotan R.; Tamir A.; Hochberg Z. (2003). "Maternal hypothyroidism may affect fetal growth and neonatal thyroid function". Obstetrics & Gynecology. 102 (2): 232–241. doi:10.1016/s0029-7844(03)00513-1. PMID 12907094. S2CID 39487202.
  3. ^ a b c Utiger Robert D (1999). "Editorial: Maternal Hypothyroidism and Fetal Development". The New England Journal of Medicine. 341 (8): 601–2. doi:10.1056/nejm199908193410809. PMID 10451467.
  4. ^ a b Ahmed O.M.; Ahmed R.G.; El-Gareib A.W.; El-Bakry A.M.; El-Tawab S.M. Abd (2012). "Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II—The developmental pattern of neurons in relation to oxidative stress and antioxidant defense system". International Journal of Developmental Neuroscience. 30 (6): 517–537. doi:10.1016/j.ijdevneu.2012.04.005. PMID 22664656. S2CID 32600950.
This page was last edited on 31 July 2023, at 03:16
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.