MTCH2

MTCH2

Identifiers

MTCH2, MIMP, SLC25A50, HSPC032, mitochondrial carrier 2

External IDs

OMIM: 613221 MGI: 1929260 HomoloGene: 8645 GeneCards: MTCH2

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11p11.2	Start	47,617,315 bp^[1]
Band	11p11.2	End	47,642,607 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 E1	Start	90,677,499 bp^[2]
Band	2\|2 E1	End	90,697,154 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

rectum

right lobe of liver

duodenum

stromal cell of endometrium

islet of Langerhans

gastrocnemius muscle

kidney

smooth muscle tissue

skeletal muscle tissue

right adrenal gland

Top expressed in

spermatid

spermatocyte

testicle

duodenum

jejunum

colon

proximal tubule

ileum

white adipose tissue

liver

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


23788


56428

Ensembl


ENSG00000109919 ENSG00000285121


ENSMUSG00000027282

UniProt


Q9Y6C9


Q791V5

RefSeq (mRNA)


NM_014342 NM_001317231 NM_001317232 NM_001317233


NM_019758 NM_001317241 NM_001317242 NM_001317243 NM_001317244

RefSeq (protein)


NP_001304160 NP_001304161 NP_001304162 NP_055157


NP_001304170 NP_001304171 NP_001304172 NP_001304173 NP_062732

Location (UCSC)

Chr 11: 47.62 – 47.64 Mb

Chr 2: 90.68 – 90.7 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.^[5]^[6]^[7]^[8]

MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID.^[9]

Clinical significance

MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis.^[9]

Variants of the MTCH2 gene may be associated with obesity.^[10] MTCH2 represses mitochondrial metabolism such that a deficiency of MTCH2 increases energy consumption and production by mitochondria.^[9]

References

^ ^a ^b ^c ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027282 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha". Molecular and Cellular Biology. 25 (11): 4579–90. doi:10.1128/MCB.25.11.4579-4590.2005. PMC 1140633. PMID 15899861.
^ Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". Journal of Bioenergetics and Biomembranes. 37 (3): 113–9. doi:10.1007/s10863-005-6222-3. PMID 16167168. S2CID 2395673.
^ Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?". Apoptosis. 12 (5): 869–76. doi:10.1007/s10495-007-0748-2. PMID 17453157.
^ Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, et al. (July 2008). Chang HY (ed.). "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers". PLOS Genetics. 4 (7): e1000129. doi:10.1371/journal.pgen.1000129. PMC 2444049. PMID 18636107.
^ ^a ^b ^c Gross A (August 2016). "BCL-2 family proteins as regulators of mitochondria metabolism". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857 (8): 1243–1246. doi:10.1016/j.bbabio.2016.01.017. PMID 26827940.
^ Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Human Molecular Genetics. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.

Yerushalmi GM, Leibowitz-Amit R, Shaharabany M, Tsarfaty I (2002). "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization". Neoplasia. 4 (6): 510–22. doi:10.1038/sj.neo.7900272. PMC 1503665. PMID 12407445.
Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, et al. (June 2010). "Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study". Obesity. 18 (6): 1212–7. doi:10.1038/oby.2009.413. PMID 19910938. S2CID 9601431.
Albers M, Kranz H, Kober I, Kaiser C, Klink M, Suckow J, et al. (February 2005). "Automated yeast two-hybrid screening for nuclear receptor-interacting proteins". Molecular & Cellular Proteomics. 4 (2): 205–13. doi:10.1074/mcp.M400169-MCP200. PMID 15604093.
Li S, Zhao JH, Luan J, Luben RN, Rodwell SA, Khaw KT, et al. (January 2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies". The American Journal of Clinical Nutrition. 91 (1): 184–90. doi:10.3945/ajcn.2009.28403. PMID 19812171.
Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA (March 2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 153B (2): 695–699. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, et al. (October 2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference". The American Journal of Clinical Nutrition. 90 (4): 951–9. doi:10.3945/ajcn.2009.27781. PMID 19692490.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L (February 2010). "Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus". Arteriosclerosis, Thrombosis, and Vascular Biology. 30 (2): 327–32. doi:10.1161/ATVBAHA.109.196196. PMC 3061473. PMID 19910641.
Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, et al. (December 2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population". Journal of Human Genetics. 54 (12): 727–31. doi:10.1038/jhg.2009.106. PMID 19851340.

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Clinical significance

See also

References

Further reading