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What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
MicroRNA 195 is a protein that in humans is encoded by the MIR195 gene.
[3]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylatedprimary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Liu L, Chen L, Xu Y, Li R, Du X (September 2010). "microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells". Biochem. Biophys. Res. Commun. 400 (2): 236–40. doi:10.1016/j.bbrc.2010.08.046. PMID20727858.
Wang X, Wang J, Ma H, Zhang J, Zhou X (June 2012). "Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer". Med. Oncol. 29 (2): 919–27. doi:10.1007/s12032-011-9880-5. PMID21390519. S2CID19566991.
Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N (October 2011). "Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation". J. Cell. Physiol. 226 (10): 2535–42. doi:10.1002/jcp.22598. PMID21792910. S2CID42464226.