Lipolysis-stimulated lipoprotein receptor

LSR

Identifiers

LSR, ILDR3, LISCH7, lipolysis stimulated lipoprotein receptor

External IDs

OMIM: 616582; MGI: 1927471; HomoloGene: 9306; GeneCards: LSR; OMA:LSR - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.12	Start	35,248,330 bp^[1]
Band	19q13.12	End	35,267,964 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B1	Start	30,657,195 bp^[2]
Band	7\|7 B1	End	30,672,889 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

body of pancreas

minor salivary glands

gallbladder

right uterine tube

skin of abdomen

rectum

body of stomach

right lobe of thyroid gland

left lobe of thyroid gland

Top expressed in

gastric mucosa

mucous cell of stomach

epithelium of stomach

crypt of lieberkuhn of small intestine

pyloric antrum

left lobe of liver

yolk sac

jejunum

duodenum

left colon

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	chylomicron integral component of membrane extracellular exosome membrane low-density lipoprotein particle very-low-density lipoprotein particle tricellular tight junction plasma membrane
Biological process	regulation of lipid metabolic process liver development establishment of blood-brain barrier tricellular tight junction assembly protein localization to tricellular tight junction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51599


54135

Ensembl


ENSG00000105699


ENSMUSG00000001247

UniProt


Q86X29


Q99KG5

RefSeq (mRNA)

NM_001260489 NM_001260490 NM_015925 NM_205834 NM_205835
NM_001385215


NM_001164184 NM_001164185 NM_017405

RefSeq (protein)


NP_001247418 NP_001247419 NP_057009 NP_991403 NP_991404


NP_001157656 NP_001157657 NP_059101

Location (UCSC)

Chr 19: 35.25 – 35.27 Mb

Chr 7: 30.66 – 30.67 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Lipolysis-stimulated lipoprotein receptor is a protein that in humans is encoded by the LSR gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105699 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001247 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yen FT, Masson M, Clossais-Besnard N, Andre P, Grosset JM, Bougueleret L, Dumas JB, Guerassimenko O, Bihain BE (Jun 1999). "Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver". J Biol Chem. 274 (19): 13390–8. doi:10.1074/jbc.274.19.13390. PMID 10224102.
^ "Entrez Gene: LSR lipolysis stimulated lipoprotein receptor".

García JM, Peña C, García V, et al. (2008). "Prognostic value of LISCH7 mRNA in plasma and tumor of colon cancer patients". Clin. Cancer Res. 13 (21): 6351–8. doi:10.1158/1078-0432.CCR-07-0882. PMID 17975147.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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This page was last edited on 3 April 2024, at 20:08

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References

Further reading