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L-745,870

From Wikipedia, the free encyclopedia

L-745,870
Identifiers
  • 3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo[2,3-b]pyridine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H19ClN4
Molar mass326.83 g·mol−1
3D model (JSmol)
  • c1cc2c(c[nH]c2nc1)CN3CCN(CC3)c4ccc(cc4)Cl
  • InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21) ☒N
  • Key:OGJGQVFWEPNYSB-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.[1][2][3]

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Transcription

References

  1. ^ Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences. 18 (6): 186–8. doi:10.1016/s0165-6147(97)01066-3. PMID 9226994.
  2. ^ Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology. 29 (9): 1648–55. doi:10.1038/sj.npp.1300491. PMID 15138447.
  3. ^ Moustgaard A, Hau J, Lind NM (2008). "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions. 4: 49. doi:10.1186/1744-9081-4-49. PMC 2577092. PMID 18945334.


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This page was last edited on 30 November 2023, at 01:08
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