IMPG1

IMPG1

Identifiers

IMPG1, GP147, IPM150, SPACR, VMD4, interphotoreceptor matrix proteoglycan 1, RP91

External IDs

OMIM: 602870 MGI: 1926876 HomoloGene: 1201 GeneCards: IMPG1

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q14.1	Start	75,921,114 bp^[1]
Band	6q14.1	End	76,072,678 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 E1\|9 43.99 cM	Start	80,220,612 bp^[2]
Band	9 E1\|9 43.99 cM	End	80,347,534 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nucleus accumbens

secondary oocyte

caudate nucleus

putamen

Brodmann area 9

right lung

prefrontal cortex

cingulate gyrus

body of pancreas

minor salivary glands

Top expressed in

retinal pigment epithelium

semi-lunar valve

left ventricle

aortic valve

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	extracellular matrix structural constituent
Cellular component	extracellular region extracellular matrix
Biological process	visual perception
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3617


63859

Ensembl


ENSG00000112706


ENSMUSG00000032343

UniProt


Q17R60


Q8R1W8

RefSeq (mRNA)


NM_001563 NM_001282368


NM_022016

RefSeq (protein)


NP_001269297 NP_001554


NP_071299

Location (UCSC)

Chr 6: 75.92 – 76.07 Mb

Chr 9: 80.22 – 80.35 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interphotoreceptor matrix proteoglycan 1 is a protein that in humans is encoded by the IMPG1 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112706 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032343 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IMPG1 interphotoreceptor matrix proteoglycan 1".

Felbor U, Gehrig A, Sauer CG, et al. (1998). "Genomic organization and chromosomal localization of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate for 6q-linked retinopathies". Cytogenet. Cell Genet. 81 (1): 12–7. doi:10.1159/000015001. PMID 9691169. S2CID 46766267.
Gehrig A, Felbor U, Kelsell RE, et al. (1998). "Assessment of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene localised to 6q13-q15 in autosomal dominant Stargardt-like disease (ADSTGD), progressive bifocal chorioretinal atrophy (PBCRA), and North Carolina macular dystrophy (MCDR1)". J. Med. Genet. 35 (8): 641–5. doi:10.1136/jmg.35.8.641. PMC 1051388. PMID 9719369.
Acharya S, Rayborn ME, Hollyfield JG (1998). "Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis". Glycobiology. 8 (10): 997–1006. doi:10.1093/glycob/8.10.997. PMID 9719680.
Acharya S, Rodriguez IR, Moreira EF, et al. (1998). "SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan". J. Biol. Chem. 273 (47): 31599–606. doi:10.1074/jbc.273.47.31599. PMID 9813076.
Kuehn MH, Hageman GS (2000). "Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan". Matrix Biol. 18 (5): 509–18. doi:10.1016/S0945-053X(99)00043-8. PMID 10601738.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
van Lith-Verhoeven JJ, Hoyng CB, van den Helm B, et al. (2004). "The benign concentric annular macular dystrophy locus maps to 6p12.3-q16". Invest. Ophthalmol. Vis. Sci. 45 (1): 30–5. doi:10.1167/iovs.03-0392. PMID 14691150.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Abd El-Aziz MM, El-Ashry MF, Barragan I, et al. (2006). "Molecular genetic analysis of two functional candidate genes in the autosomal recessive retinitis pigmentosa, RP25, locus". Curr. Eye Res. 30 (12): 1081–7. doi:10.1080/02713680500351039. PMID 16354621. S2CID 26204316.

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This page was last edited on 18 August 2023, at 08:28

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References

Further reading