ICAM5

ICAM5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3BN3, 4OI9, 4OIA, 4OIB

Identifiers

Aliases

ICAM5, TLCN, TLN, intercellular adhesion molecule 5

External IDs

OMIM: 601852 MGI: 109430 HomoloGene: 2447 GeneCards: ICAM5

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.2	Start	10,289,952 bp^[1]
Band	19p13.2	End	10,296,778 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 A3\|9 7.7 cM	Start	20,943,369 bp^[2]
Band	9 A3\|9 7.7 cM	End	20,950,332 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

prefrontal cortex

cingulate gyrus

nucleus accumbens

dorsolateral prefrontal cortex

Brodmann area 9

caudate nucleus

frontal pole

hippocampus proper

middle frontal gyrus

amygdala

Top expressed in

entorhinal cortex

superior frontal gyrus

hippocampus proper

Region I of hippocampus proper

nucleus accumbens

prefrontal cortex

amygdala

cingulate gyrus

primary motor cortex

subiculum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	integrin binding protein binding
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	cell adhesion phagocytosis regulation of immune response extracellular matrix organization cell-cell adhesion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7087


15898

Ensembl


ENSG00000105376


ENSMUSG00000032174

UniProt


Q9UMF0


Q60625

RefSeq (mRNA)


NM_003259


NM_008319

RefSeq (protein)


NP_003250


NP_032345

Location (UCSC)

Chr 19: 10.29 – 10.3 Mb

Chr 9: 20.94 – 20.95 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.^[7]

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Interactions

ICAM5 has been shown to interact with PSEN1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105376 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032174 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K (Feb 1997). "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol Chem. 272 (2): 1156–63. doi:10.1074/jbc.272.2.1156. PMID 8995416.
^ Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM (Jan 1999). "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2". Genomics. 54 (2): 328–30. doi:10.1006/geno.1998.5565. PMID 9828136.
^ ^a ^b "Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin".
^ Annaert, W G; Esselens C; Baert V; Boeve C; Snellings G; Cupers P; Craessaerts K; De Strooper B (Nov 2001). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi:10.1016/S0896-6273(01)00512-8. ISSN 0896-6273. PMID 11719200. S2CID 2096602.

Yoshihara Y, Mori K (1995). "Telencephalin: a neuronal area code molecule?". Neurosci. Res. 21 (2): 119–24. doi:10.1016/0168-0102(94)90153-8. PMID 7724062. S2CID 19931440.
Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions". Immunol. Res. 17 (3): 313–27. doi:10.1007/BF02786454. PMID 9638475. S2CID 19901365.
Benson DL, Yoshihara Y, Mori K (1998). "Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule". J. Neurosci. Res. 52 (1): 43–53. doi:10.1002/(SICI)1097-4547(19980401)52:1<43::AID-JNR5>3.0.CO;2-K. PMID 9556028. S2CID 22675478.
Rieckmann P, Turner T, Kligannon P, Steinhoff BJ (1998). "Telencephalin as an indicator for temporal-lobe dysfunction". Lancet. 352 (9125): 370–1. doi:10.1016/S0140-6736(05)60469-2. PMID 9717930. S2CID 6255738.
Arii N, Mizuguchi M, Mori K, Takashima S (1999). "Development of telencephalin in the human cerebrum". Microsc. Res. Tech. 46 (1): 18–23. doi:10.1002/(SICI)1097-0029(19990701)46:1<18::AID-JEMT2>3.0.CO;2-G. PMID 10402269. S2CID 22133468.
Mizuno T, Yoshihara Y, Kagamiyama H, et al. (2000). "Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia". Brain Res. 849 (1–2): 58–66. doi:10.1016/S0006-8993(99)01984-8. PMID 10592287. S2CID 353053.
Tian L, Kilgannon P, Yoshihara Y, et al. (2000). "Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18". Eur. J. Immunol. 30 (3): 810–8. doi:10.1002/1521-4141(200003)30:3<810::AID-IMMU810>3.0.CO;2-X. PMID 10741396.
Tian L, Nyman H, Kilgannon P, et al. (2000). "Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion". J. Cell Biol. 150 (1): 243–52. doi:10.1083/jcb.150.1.243. PMC 2185561. PMID 10893271.
Annaert WG, Esselens C, Baert V, et al. (2002). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi:10.1016/S0896-6273(01)00512-8. PMID 11719200. S2CID 2096602.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Cox DG, Hankinson SE, Hunter DJ (2006). "Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk". Cancer Epidemiol. Biomarkers Prev. 15 (1): 178–9. doi:10.1158/1055-9965.EPI-05-0790. PMID 16434609.

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This page was last edited on 8 November 2023, at 10:17

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Interactions

References

Further reading