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Hyzetimibe

From Wikipedia, the free encyclopedia

Hyzetimibe
Clinical data
Other namesHS-25
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (3R,4S)-1-(4-Fluorophenyl)-3-((Z)-3-(4-fluorophenyl)-4-hydroxy-but-2-enyl)-4-(4-hydroxyphenyl)azetidin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC25H21F2NO3
Molar mass421.444 g·mol−1
  • InChI=InChI=1S/C25H21F2NO3/c26-19-6-1-16(2-7-19)18(15-29)5-14-23-24(17-3-12-22(30)13-4-17)28(25(23)31)21-10-8-20(27)9-11-21/h1-13,23-24,29-30H,14-15H2/b18-5+/t23-,24-/m1/s1
  • Key:HEHHPZYUXSFAPV-SMOXZEHUSA-N

Hyzetimibe is a pharmaceutical drug that inhibits cholesterol absorption.[1][2] It targets the NPC1-like intracellular cholesterol transporter 1.[2]

In China, it is used as a lipid-lowering agent and it has efficacy similar to ezetimibe.[3]

References

  1. ^ Ruan Z, Jiang B, Chen J, Zhang X, Lou H, Xiang M, et al. (October 2014). "Pharmacokinetics, pharmacodynamics, safety, and tolerability of hyzetimibe (HS-25) in healthy Chinese subjects". Journal of Clinical Pharmacology. 54 (10): 1144–1152. doi:10.1002/jcph.310. PMID 24752831.
  2. ^ a b Liao J, Yang L, Zhou L, Zhao H, Qi X, Cui Y, Ouyang D (2022). "The NPC1L1 Gene Exerts a Notable Impact on the Reduction of Low-Density Lipoprotein Cholesterol in Response to Hyzetimibe: A Factorial-Designed Clinical Trial". Frontiers in Pharmacology. 13: 755469. doi:10.3389/fphar.2022.755469. PMC 8963242. PMID 35359877.
  3. ^ Li JJ, Zhao SP, Zhao D, Lu GP, Peng DQ, Liu J, et al. (2023). "2023 Chinese guideline for lipid management". Frontiers in Pharmacology. 14: 1190934. doi:10.3389/fphar.2023.1190934. PMC 10498001. PMID 37711173.
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This page was last edited on 11 May 2024, at 22:52
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