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Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8gene.[5][6][7]
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics. 35 (3): 600–2. doi:10.1006/geno.1996.0405. PMID8812499.
Kikuti YY, Tamiya G, Ando A, et al. (1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes". Genomics. 42 (3): 422–35. doi:10.1006/geno.1997.4745. PMID9205114.
Aziz N, Anderson E, Lee GY, Woo DD (2001). "Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism". Mol. Cell. Endocrinol. 171 (1–2): 83–8. doi:10.1016/S0303-7207(00)00390-7. PMID11165015. S2CID20566396.
Song D, Liu G, Luu-The V, et al. (2006). "Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study". J. Steroid Biochem. Mol. Biol. 101 (2–3): 136–44. doi:10.1016/j.jsbmb.2006.06.015. PMID16930994. S2CID27619774.
Villar J, Celay J, Alonso MM, et al. (2007). "Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta". J. Steroid Biochem. Mol. Biol. 105 (1–5): 131–9. doi:10.1016/j.jsbmb.2006.12.106. PMID17583490. S2CID54404567.