HSD17B11

HSD17B11

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YB1

Identifiers

Aliases

HSD17B11, 17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2, hydroxysteroid (17-beta) dehydrogenase 11, hydroxysteroid 17-beta dehydrogenase 11

External IDs

OMIM: 612831; MGI: 2149821; HomoloGene: 69209; GeneCards: HSD17B11; OMA:HSD17B11 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q22.1	Start	87,336,515 bp^[1]
Band	4q22.1	End	87,391,188 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 E5	Start	104,137,628 bp^[2]
Band	5\|5 E5	End	104,169,785 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

mucosa of colon

duodenum

mucosa of sigmoid colon

rectum

mucosa of ileum

monocyte

gallbladder

mucosa of transverse colon

blood

Top expressed in

vestibular membrane of cochlear duct

pyloric antrum

epithelium of stomach

mucous cell of stomach

iris

intestinal villus

stria vascularis

Ileal epithelium

left lobe of liver

duodenum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	oxidoreductase activity steroid dehydrogenase activity estradiol 17-beta-dehydrogenase activity
Cellular component	cytoplasm extracellular region cytosol lipid droplet
Biological process	estrogen biosynthetic process androgen catabolic process lipid metabolism steroid biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51170


114664

Ensembl


ENSG00000198189


ENSMUSG00000029311

UniProt


Q8NBQ5


Q9EQ06

RefSeq (mRNA)


NM_016245


NM_053262

RefSeq (protein)


NP_057329


NP_444492

Location (UCSC)

Chr 4: 87.34 – 87.39 Mb

Chr 5: 104.14 – 104.17 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.^[5]^[6]^[7]^[8]

HSD17B11 expression has been linked to higher survival rates for lung cancer patients.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198189 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029311 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z (January 2001). "Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung". Molecular and Cellular Endocrinology. 171 (1–2): 111–7. doi:10.1016/S0303-7207(00)00417-2. PMID 11165019. S2CID 54263651.
^ Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology. 144 (5): 2084–91. doi:10.1210/en.2002-221030. PMID 12697717.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11".
^ "Research update from the MCM team (March 2024)". World Community Grid. 14 March 2024. Retrieved 21 May 2024.

Li KX, Smith RE, Krozowski ZS (1999). "Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase". Endocrine Research. 24 (3–4): 663–7. doi:10.3109/07435809809032667. PMID 9888557.
Haeseleer F, Palczewski K (2000). "Short-chain dehydrogenases/Reductases in retina". Vertebrate Phototransduction and the Visual Cycle, Part B. Methods in Enzymology. Vol. 316. pp. 372–83. doi:10.1016/S0076-6879(00)16736-9. ISBN 978-0-12-182217-0. PMID 10800688.
Hartmann TB, Thiel D, Dummer R, Schadendorf D, Eichmüller S (February 2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". The British Journal of Dermatology. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095. S2CID 42495130.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

v t e PDB gallery
1yb1: Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI

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This page was last edited on 21 May 2024, at 17:39

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References

Further reading