Generation R is a prospective, population based cohort study from fetal life until young adulthood in a multi-ethnic urban population in Rotterdam, the Netherlands.[1] The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health.[2] Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.[3]
The study focuses on five primary areas of research:
- Growth and physical development
- Behavioral and cognitive development
- Asthma and atopy
- Diseases in childhood
- Health and healthcare
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Study cohort
The children form a prenatally recruited birth cohort that will be followed until young adulthood. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Of all eligible children at birth, 61% participate in the study. A large part of this study cohort consists of ethnic minorities.
Data collection
Data collection in the prenatal phase included physical examinations, questionnaires, foetal ultrasound examinations and biological samples. In addition, more detailed assessments are conducted in a subgroup of 1232 pregnant women and their children. At the age of 5 years, all children were invited to visit the Generation R research centre for detailed assessments. This was repeated at the age of 9 years.
Publications
A list of publications from the Generation R study.
References
- ^ Acton, Q.A. (2012). Post-Partum Depression: New Insights for the Healthcare Professional: 2011 Edition: ScholarlyPaper. ScholarlyEditions. p. 1. ISBN 978-1-4649-1614-4. Retrieved February 25, 2018.
- ^ Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van IJzendoorn MH, de Jongste JC, van der Lugt A, Mackenbach JP, Moll HA, Raat H, Rivadeneira F, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A. The Generation R Study: design and cohort update 2012. Eur J Epidemiol
- ^ Higher Education in Regional and City Development Higher Education in Regional and City Development: Rotterdam, The Netherlands 2010. Higher Education in Regional and City Development. OECD Publishing. 2010. p. 100. ISBN 978-92-64-08896-2. Retrieved February 25, 2018.
Further reading
- Jaddoe, V.W.; van Duijn, CM.; van der Heijden, AJ.; Mackenbach, JP.; Moll, HA.; Steegers, EA.; Tiemeier, H.; Uitterlinden, AG.; Verhulst, FC.; Hofman, A. (22 October 2010). "The Generation R Study: design and cohort update 2010". European Journal of Epidemiology. 25 (11): 823–841. doi:10.1007/s10654-010-9516-7. PMC 2991548. PMID 20967563.
- Jaddoe, V.W.; van Duijn, CM.; van der Heijden, AJ.; Mackenbach, JP.; Moll, HA.; Steegers, EA.; Tiemeier, H.; Uitterlinden, AG.; Verhulst, FC.; Hofman, A. (20 December 2008). "The Generation R Study: design and cohort update until the age of 4 years". European Journal of Epidemiology. 23 (12): 801–811. doi:10.1007/s10654-008-9309-4. PMID 19101808. S2CID 13000610.
- Jaddoe, V.W.; Bakker, R.; van Duijn, CM.; van der Heijden, AJ.; Lindemans, J.; Mackenbach, JP.; Moll, HA.; Steegers, EA.; Tiemeier, H.; Uitterlinden, AG.; Verhulst, FC.; Hofman, A. (19 December 2007). "The Generation R Study Biobank: a resource for epidemiological studies in children and their parents". European Journal of Epidemiology. 22 (12): 917–923. doi:10.1007/s10654-007-9209-z. PMC 2190786. PMID 18095172.
- Jaddoe, V.W.; Mackenbach, JP.; Moll, HA.; Steegers, EA.; Tiemeier, H.; Verhulst, FC.; Witteman, JC.; Hofman A. (7 July 2006). "The Generation R Study: Design and cohort profile". European Journal of Epidemiology. 21 (6): 475–484. doi:10.1007/s10654-006-9022-0. PMID 16826450. S2CID 7874868.
- Hofman, A.; Jaddoe, VW.; Mackenbach, JP.; Moll, HA.; Snijders, RF.; Steegers, EA.; Verhulst, FC.; Witteman, JC.; Büller, HA. (January 2004). "Growth, development and health from early fetal life until young adulthood: the Generation R Study". Paediatric and Perinatal Epidemiology. 18 (1): 61–72. doi:10.1111/j.1365-3016.2003.00521.x. PMID 14738548.
External links
- http://www.generationr.nl/ Website of the study
This page was last edited on 2 October 2020, at 11:04