GREB1

GREB1

Identifiers

GREB1, growth regulation by estrogen in breast cancer 1, growth regulating estrogen receptor binding 1

External IDs

OMIM: 611736 MGI: 2149712 HomoloGene: 8780 GeneCards: GREB1

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p25.1	Start	11,482,341 bp^[1]
Band	2p25.1	End	11,642,788 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 A1.1	Start	16,720,616 bp^[2]
Band	12\|12 A1.1	End	16,850,887 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

germinal epithelium

canal of the cervix

left uterine tube

myometrium

right uterine tube

prostate

endometrium

vagina

caput epididymis

smooth muscle tissue

Top expressed in

cumulus cell

primitive streak

adrenal gland

substantia nigra

Paneth cell

ovary

trigeminal ganglion

Bowman's capsule

ciliary body

yolk sac

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


9687


268527

Ensembl


ENSG00000196208


ENSMUSG00000036523

UniProt


Q4ZG55


Q3UHK3

RefSeq (mRNA)


NM_014668 NM_033090 NM_148903


NM_001252071 NM_015764

RefSeq (protein)


NP_055483 NP_149081 NP_683701


NP_001239000 NP_056579

Location (UCSC)

Chr 2: 11.48 – 11.64 Mb

Chr 12: 16.72 – 16.85 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene.^[5]

YouTube Encyclopedic

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Transcription

Function

This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196208 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036523 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Growth regulation by estrogen in breast cancer 1".

Hnatyszyn HJ, Liu M, Hilger A, Herbert L, Gomez-Fernandez CR, Jorda M, Thomas D, Rae JM, El-Ashry D, Lippman ME (2010). "Correlation of GREB1 mRNA with protein expression in breast cancer: Validation of a novel GREB1 monoclonal antibody". Breast Cancer Research and Treatment. 122 (2): 371–80. doi:10.1007/s10549-009-0584-x. PMID 19842031. S2CID 22189668.
Deschênes J, Bourdeau V, White JH, Mader S (2007). "Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences". Journal of Biological Chemistry. 282 (24): 17335–9. doi:10.1074/jbc.C700030200. PMID 17463000.
Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD (2012). "The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation". PLOS ONE. 7 (2): e31593. Bibcode:2012PLoSO...731593C. doi:10.1371/journal.pone.0031593. PMC 3281101. PMID 22359603.
Pellegrini C, Gori I, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2012). "The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis". Fertility and Sterility. 98 (5): 1200–8. doi:10.1016/j.fertnstert.2012.06.056. PMID 22884659.
Liu M, Wang G, Gomez-Fernandez CR, Guo S (2012). "GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer". PLOS ONE. 7 (10): e46410. Bibcode:2012PLoSO...746410L. doi:10.1371/journal.pone.0046410. PMC 3463574. PMID 23056300.
Nyholt DR, Low SK, Anderson CA, Painter JN, Uno S, Morris AP, MacGregor S, Gordon SD, Henders AK, Martin NG, Attia J, Holliday EG, McEvoy M, Scott RJ, Kennedy SH, Treloar SA, Missmer SA, Adachi S, Tanaka K, Nakamura Y, Zondervan KT, Zembutsu H, Montgomery GW (2012). "Genome-wide association meta-analysis identifies new endometriosis risk loci" (PDF). Nature Genetics. 44 (12): 1355–9. doi:10.1038/ng.2445. PMC 3527416. PMID 23104006.
Rae JM, Johnson MD, Cordero KE, Scheys JO, Larios JM, Gottardis MM, Pienta KJ, Lippman ME (2006). "GREB1 is a novel androgen-regulated gene required for prostate cancer growth". The Prostate. 66 (8): 886–94. doi:10.1002/pros.20403. hdl:2027.42/49275. PMID 16496412. S2CID 24744169.
Rittié L, Kang S, Voorhees JJ, Fisher GJ (2008). "Induction of collagen by estradiol: Difference between sun-protected and photodamaged human skin in vivo". Archives of Dermatology. 144 (9): 1129–40. doi:10.1001/archderm.144.9.1129. PMID 18794456.
Ghosh MG, Thompson DA, Weigel RJ (2000). "PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer". Cancer Research. 60 (22): 6367–75. PMID 11103799.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 3 March 2023, at 21:06

From Wikipedia, the free encyclopedia

YouTube Encyclopedic

Transcription

Function

References

Further reading