File:Steroidogenesis.svg

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Enzymes, their cellular location, substrates and products in human steroidogenesis. Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids. White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see structural formula. HSD: Hydroxysteroid dehydrogenase References: Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3. For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013). There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase. Further reading: Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824. Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024. See also: Wikiversity:Diagram of the pathways of human steroidogenesis

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Summary

DescriptionSteroidogenesis.svg	Enzymes, their cellular location, substrates and products in human steroidogenesis. Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids. White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see structural formula. HSD: Hydroxysteroid dehydrogenase References: Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3. For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013). There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase. Further reading: Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824. Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024. See also: Wikiversity:Diagram of the pathways of human steroidogenesis
Date	28 March 2009
Source	Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
Author	David Richfield (Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr. In external use, this diagram may be cited as: (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20018762.
Other versions	edit Original. See also Evolution. Raster (.png) version is available Translations 中文國語 Русский Galego العربية polski German 日本語
SVG development InfoField	The SVG code is valid. This structural formula was created with Inkscape. The chemistry symbols of this structural formula are drawn using the path text method.


	This is a featured picture on the English language Wikipedia (Featured pictures) and is considered one of the finest images. See its nomination here. If you think this file should be featured on Wikimedia Commons as well, feel free to nominate it. If you have an image of similar quality that can be published under a suitable copyright license, be sure to upload it, tag it, and nominate it.

Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.

5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.

Licensing

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	The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission. CC0falsefalse

File history

Click on a date/time to view the file as it appeared at that time.

	Date/Time	Dimensions	User	Comment
current	09:21, 8 May 2024	1,245 × 1,105 (251 KB)	Bjankuloski06	File uploaded using svgtranslate tool (https://svgtranslate.toolforge.org/). Added translation for mk.
	10:52, 28 October 2022	1,245 × 1,105 (224 KB)	Uxue García	File uploaded using svgtranslate tool (https://svgtranslate.toolforge.org/). Added translation for eu.
	15:58, 8 April 2020	1,245 × 1,105 (198 KB)	Ата	File uploaded using svgtranslate tool (https://tools.wmflabs.org/svgtranslate/). Added translation for uk.
	15:54, 8 April 2020	1,245 × 1,105 (187 KB)	Ата	File uploaded using svgtranslate tool (https://tools.wmflabs.org/svgtranslate/). Added translation for uk.
	15:12, 13 March 2013	1,245 × 1,105 (133 KB)	Slashme	Removed arrow from Corticosterone to Cortisol via CYP17A1 (see http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )
	16:15, 9 July 2012	1,245 × 1,105 (133 KB)	Mikael Häggström	Addition and correction of stereochemistries at positions 11 and 17.
	04:24, 9 July 2012	1,245 × 1,105 (127 KB)	Mikael Häggström	Added stereochemistries, removed redundant white circle at cortisol, renamed 21-alpha hydroxylase to simply 21-hydroxylase.
	05:15, 13 December 2011	1,245 × 1,105 (114 KB)	Slashme	Align some text and arrows for neatness' sake.
	04:56, 13 December 2011	1,245 × 1,105 (114 KB)	Slashme	Fixed reaction scheme: corticosterone doesn't go to cortisol! Karl and Lindie, why didn't you fix it when you first found out? Tsk tsk.
	12:58, 8 May 2010	1,245 × 1,105 (114 KB)	Mikael Häggström	minor move of 5-a-reductase