FBXO9

FBXO9
Identifiers
Aliases	FBXO9, FBX9, NY-REN-57, VCIA1, dJ341E18.2, F-box protein 9
External IDs	OMIM: 609091 MGI: 1918788 HomoloGene: 8217 GeneCards: FBXO9
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.1 Start 53,051,991 bp[1] End 53,100,873 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E1 Start 77,988,781 bp[2] End 78,016,347 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus right adrenal gland secondary oocyte left adrenal gland trabecular bone tibia parotid gland Brodmann area 10 Top expressed in medial vestibular nucleus blood ciliary body retinal pigment epithelium dorsal tegmental nucleus pontine nuclei motor neuron medial geniculate nucleus ventral tegmental area substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component cytoplasm ubiquitin ligase complex SCF ubiquitin ligase complex cytosol Biological process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process innate immune response regulation of TOR signaling fat cell differentiation protein ubiquitination protein polyubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26268 71538 Ensembl ENSG00000112146 ENSMUSG00000001366 UniProt Q9UK97 Q8BK06 RefSeq (mRNA) NM_012347 NM_033480 NM_033481 NM_001081490 NM_023605 RefSeq (protein) NP_036479 NP_258441 NP_258442 NP_001074959 NP_076094 Location (UCSC) Chr 6: 53.05 – 53.1 Mb Chr 9: 77.99 – 78.02 Mb PubMed search [3] [4]
Wikidata
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F-box only protein 9 is a protein that in humans is encoded by the FBXO9 gene.^[5][6][7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus.^[7]

References

Further reading

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This page was last edited on 30 March 2024, at 02:33